The Allergic Lung Flashcards
1
Q
What causes the switch in B cells from IgM to IgE?
A
• First signal is by IL-4 or IL-13
The second signal is when CD14 on B cells binds to its ligand on T cells
2
Q
What are the clinical features of bronchial asthma?
A
- Acute attacks of SOB due to contraction of smooth muscle
- Mucus hypersecretion
- Airway inflammation
- Bronchial hyper-responsiveness
3
Q
Which cytokine prolongs the survival of eosinophils?
A
IL-5
4
Q
Outline the phases of asthma
A
- Bronchospasm – lasts 2 hours past exposure to trigger
* Inflammation – occurs about 4 hours after a trigger and lasts for about 3 hours
5
Q
What cytokines regulate eosinophils?
A
IL-3, IL-5
