Innate Response and Th1/Th2 Flashcards
1
Q
What cytokines do macrophages secrete?
A
TNFa, IL-1, IL-6, IL-8
2
Q
Which cytokine stimulates Th1 cells to be developed
A
IL-12
3
Q
Which cytokine stimulates Th2 cells to be developed
A
IL-4
4
Q
Whats the function of Th1 cells?
A
Secrete IFNg to activate cell-mediated immunity (helps CD8+ T cells and macrophages)
5
Q
Whats the function of Th2 cells?
A
Secrete IL-4, IL-5 and IL-13 to aid humoral immunity (helps B cells produce antibodies)
6
Q
Which type of T cell is associated with allergy?
A
Th2; produces IL-4 which leads to IgE production –> allergies
7
Q
Which type of T cell produces more limited (rather than disseminated) disease?
A
Th1 = limited disease Th2 = disseminated disease
