PH: Cancer Epidemiology

Question 1

Why do most cancers develop in epithelial tissues?

Answer 1

Due to a higher rate of mitosis and epithelial cells are exposed to environmental factors.

Question 2

Which cancers have a good prognosis?

Answer 2

Skin (non-melanoma) doesn’t metastasise, those which present with early symptoms, cancers of children and adolescents and cancers that we screen for

Question 3

What (dominant) mutations are associated with breast cancer?

Answer 3

BRCA1/2

Question 4

What (dominant) mutations are associated with retinoblastoma?

Answer 4

Retinoblastoma gene

Question 5

What (dominant) mutations are associated with colorectal cancer?

Answer 5

FAP, HNTCC

Question 6

What (dominant) mutations are associated with stomach and colorectal cancers

Answer 6

Peutz-Jeghers (polyps)

Question 7

What (dominant) mutations are associated with fibrosarcoma?

Answer 7

von Recklinghausen’s

Question 8

What (recessive) mutations are associated with skin cancer?

Answer 8

xeroderma pigmentosum

Question 9

What (recessive) mutations are associated with leukaemia?

Answer 9

ataxia telangiectasia