Drug Interactions Flashcards

1
Q

Outline the phases of drug trials

A

Phase 1 = safety & toxicity in health subjects
Phase 2 = first assessment in patients, dose range identified
Phase 3 = tests efficacy in wider patient population
Phase 4 = post-marketing surveillance of adverse effects, efficacy, safety and toxicity

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2
Q

What is involved in phase 1 of drug trials?

A

Healthy human subjects to assess SAFETY and TOXICITY. About 100 subjects.

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3
Q

What is involved in phase 2 of drug trials?

A

DOSE RANGE IDENTIFIED in patients, monitor pharmacokinetics/dynamics. Usually about 500 subjects.

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4
Q

What is involved in phase 3 of drug trials?

A

TESTS EFFICACY, used in the wider patient population. Usually 2000 patients with multi-centre trials

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5
Q

What is involved in phase 4 of drug trials?

A

Post-marketing surveillance: efficacy, safety, toxicity and adverse effects monitored

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6
Q

Which drugs can interact with warfarin?

A

Cimetidine, erythromycin, ciprofloxacin, sulphonamides

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7
Q

Which drugs can interact with theophylline?

A

Cimetidine, erythromycin –> can cause convulsions/arrhythmias

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8
Q

Which drugs can interact with digoxin?

A

Amiodarone, verapamil, quinidine, diuretics –> arrhythmias and heart block

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9
Q

Which drugs can interact with beta-blockers?

A

Verapamil and diltiazem (non-dihydropyridine CCBs) –> bradycardia and systole

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10
Q

Which drugs can interact with lithium

A

Thiazide diuretics –> ataxia, convulsions

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11
Q

Which drugs can interact with azathioprine/mercaptopurine?

A

Allopurinol –> bone marrow failure

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12
Q

Which drugs can interact with phenytoin?

A

Isoniazide, sulphonamides -> ataxia

COCP –> reduced effect

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13
Q

Which anti-emetic drug accelerates gastric emptying?

A

Metoclopramide

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