Terbinafine, Nystatin and other Antifungals

Question 1

Which antifungal is used to treat toenail fungus in humans, and is becoming an alternative treatment for superficial dermatophytosis including Aspergillus?

Answer 1

Terbinafine

Question 2

What is the mechanism of action of Terbinafine?

Answer 2

Works by damaging the fungal cellular membrane

Question 3

Why must Terbinafine be given orally?

Answer 3

Because topically applied forms will not deliver the drug.

Question 4

What are the side effects of Terbinafine?

Answer 4

GI upset with a low risk of hepatotoxicity

Question 5

What antifungal is often included with topical antibiotic/corticosteroid ointment?

Answer 5

Nystatin

Question 6

What antifungal is considered to be very nephrotoxic and therfore its use is strictly limited to topical application?

Answer 6

Nystatin

Question 7

What other antifungal agent is used synergistically with amphotericin B to enhance its antifungal properties?

Answer 7

Flucyrosine

Question 8

What antiparasitic is widely promoted on the internet for control of ringworm in catteries or in households with many cats?

Answer 8

Lufenuron

Question 9

What does Lufenuron interfere with?

Answer 9

Chitin
Which is found in the exoskeleton of insects, the egg-tooth of flea larva and the cell wall of fungal elements which is why it is thought to be an antifungal

Question 10

True or False: Clinical studies have proven Lufenuron effectiveness in controlling superficial dermatophytosis and there is clearly benefit for use in multicat households

Answer 10

False