Griseofulvin Flashcards
What is a fungistatic drug that has been replaced by itraconazole to some extent?
Griseofulvin
What is Griseofulvin used primarily to treat?
Trichophyton and Microsporum infections
What is the only FDA-approved drug for systemtic administration to treat superficial fungal diseases?
Griseofulvin
What is available as an oral microsized powder and needs to be given with fatty foods in order to be absorbed by the GI tract?
Griseofulvin
What is the mechanism of action of Griseofulvin?
Impairing microtubules that make up the structure of the fungal cell wall
What does impairing the fungal microtubules accomplish?
Inhibits the fungal agent but does not immediately kill it. Slows the rate at which the fungus is eliminated from the body
Where does Griseofulvin accumulate?
The deepest part of the skin where the youngest cells are found. The young cells bring Griseofulvin to the surface
What is Griseofulvin metabolized by?
The liver
Griseofulvin is often conjugated with what other drug?
Glucuronide
Why are doses for griseofulvin/glucuronide lower in cats than dogs?
Cats are slow to conjugate any drug with glucuronide, which means they eliminate griseofulvin slowly, which allows for the drug concentration to accumulate to toxic levels
Griseofulvin is what in cats at high doses?
Teratogenic. Produces birth defects
What are the side effects of Griseofulvin?
Anorexia, Vomiting, Diarrhea
Anemia, Leukopenia are rare at normal dosages
