Chloramphenicol and Florfenicol

Question 1

Is Chloramphenicol bacteriostatic or bactericidal?

Answer 1

Both.
Bacteriostatic at low doses
Bactericidal at higher doses

Question 2

What is the mechanism of action for Chloramphenicol?

Answer 2

Binding to the ribosomes and disrupting bacterial protein synthesis

Question 3

What side effect associated with Chloramphenicol is reported in humans but not animals?

Answer 3

Aplastic anemia

Question 4

What is Chloramphenicol metabolized by

Answer 4

The liver (the glucronide conjunction in the liver)

Question 5

Is chloramphenicol or florfenicol a newer antibiotic?

Answer 5

Florfenicol

Question 6

What is florfenicol used for?

Answer 6

It can be safely used in cattle for bovine respiratory diseases

Question 7

Is Florfenicol bacteriostatic or bactericidal?

Answer 7

Bacteriostatic

Question 8

What is the mechanism of action of Florfenicol?

Answer 8

It disrupts protein synthesis

Question 9

What makes florfenicol safer than chloramphicol?

Answer 9

Florfenicol lacks the chemical component that makes chloramphenicol toxic

Question 10

What is the withdrawal time of Florfenicol if it is administered as a single SQ injection?

Answer 10

38 days

Question 11

What is the withdrawal time is florfenicol is used as two IM doses?

Answer 11

28 days