Lincosamides

Question 1

What are examples of Lincosamides?

Answer 1

Lincomycin
Clindamycin
Pirlimycin

Question 2

Lincomycin is approved in what species?

Answer 2

Dogs
Cats
Swine
Poultry

Question 3

Clindamycin is approved for use only in what species?

Answer 3

Dogs

Question 4

What bacteria does Clindamycin have good efficacy against?

Answer 4

Anaerobic bacteria

Question 5

Pirlimycin is approved for what species?

Answer 5

Dairy cattle as a mammary infusion for mastitis

Question 6

What are the withdrawal times for milk and tissue residues in dairy cattle that were treated with Pirlimycin?

Answer 6

36 hours after the last treatment in milk

9 to 21 days after last treatment for tissue residues

Question 7

What is the mechanism of action for Lincosamides?

Answer 7

Protein inhibitors

Question 8

Are Lincosamides Bacteriostatic or Bactericidal?

Answer 8

They can be both depending on the concentrations at the infection site

Question 9

Lincosamides are effective against what kind of bacteria?

Answer 9

gram-positive cocci

Question 10

What are Lincosamides metabolized by and excreted by?

Answer 10

Metabolized in the liver and excreted in the urine or bile.

Question 11

What can severe liver or renal disease do to Lincosamides?

Answer 11

Can prolong the half-life of elimination which makes it necessary to reduce the dose to prevent toxicity

Question 12

Lincosamides are contraindicated in what species?

Answer 12

Rabbits
Hamsters
Chinchillas
Guinea pig
Horses
Ruminants

Question 13

What are the side effects of Lincosamides in dogs and cats?

Answer 13

Vomiting
Diarrhea
Bloody diarrhea