teratogens Flashcards
renal damage
ace inhibitors
absence of digits/multiple anomalies
alkylating agents
CN VIII toxicity
aminoglycosides
facial dsymorphism, developmental delay, neural tube defects, phalanx/fingernail hypoplasia
carbamazepine
vaginal clear cell adenocarcinoma, congenital mullerian anomalies
DES
neural tube defects
folate antagonists
multiple severe birth defects
isotretinoin
atrialized right ventricle
lithium
aplasia cutis congenita
methimazole
fetal hydantoin syndrome - cleft palate, cardiac defects, phalanx/fingernail hypoplasia
phenytoin
discolored teeth
tetracyclines
limb defects - phocomelia, micromelia, flipper limbs
thalidomide
inhibition of maternal folate absorption leading to neural tube defects
valproate
bone deformities, fetal hemorrhage, abortion, opthalmologic abnormalities
warfarin
placental abruption
cocaine
IUGR, ADHD, preterm labor, placental problems, low birth weight
smoking, nicotine
nicotine causes what
vasoconstriction
extremely high risk for spontaneous abortions and birth defects such as cleft palate and cardiac defects
vit a excess
microcephaly, intellectual disability
xrays
when are u most susceptible to teratogens
week 3-8
