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STEP 1 > Immuno > Flashcards

Immuno Flashcards

1
Q

Lymph drainage: head and neck

A

cervical

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2
Q

Lymph drainage: lungs

A

hilar

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3
Q

Lymph drainage: Trachea and esophageal

A

mediastinal

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4
Q

Lymph drainage: Upper limb, breast, skin above umbilicus

A

axillary

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5
Q

Lymph drainage: Liver, stomach, spleen, pancreas, upper duodenum

A

celiac

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6
Q

Lymph drainage: lower duodenum, jejunum, ileum, colon, up to splenic flexure

A

superior mesenteric

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7
Q

Lymph drainage: colon from splenic flexure to upper rectum

A

inferior mesenteric

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8
Q

Lymph drainage: Lower rectum to anal canal (above pectinate line), bladder, vagina (middle third), prostate

A

internal iliac

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9
Q

Lymph drainage: testes, ovaries, kidneys, uterus

A

para-aortic

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10
Q

Lymph drainage: Anal canal (below pectinate line), skin below umbilicus except popliteal territory, scrotum

A

superficial inguinal

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11
Q

Lymph drainage: dorsolateral foot, posterior calf

A

popliteal

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12
Q

HLA: hemochromatosis

A

A3

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13
Q

HLA: PAIR syndromes (psoriatic arthritis, ankylosing spondylitis, IBD, Reactive arthritis)

A

B27

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14
Q

HLA: Celiac disease

A

DQ2/DQ8

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15
Q

HLA: MS

A

DR2

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16
Q

HLA: hay fever

A

DR2

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17
Q

HLA: SLE

A

DR2/DR3

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18
Q

HLA: Goodpasture

A

DR2

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19
Q

HLA: DM 1

A

DR3, DR4

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20
Q

HLA: Graves disease

A

DR3

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21
Q

HLA: Hashimoto

A

DR3/ DR5

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22
Q

HLA: Rheumatoid arthritis

A

DR4

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23
Q

HLA: Pernicious anemia/b12 deficiency

A

DR5

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24
Q

MHC class 1 are encoded by

A

HLA-A, HLA-B, HLA-C

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25
Q

MHC class II are encoded by

A

HLA-DQ, HLA-DP, HLA-DR

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26
Q

What cytokines increase NK cell proliferation?

A

IL-2, IL-12, IFN alpha, IFN beta

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27
Q

Name the disease: Anti-ACh receptor

A

Myasthenia gravis

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28
Q

Name the disease: Anti-BM

A

Goodpasture syndrome

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29
Q

Name the disease: Anticardiolipin

A

SLE/antiphosholipid syndrome

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30
Q

Name the disease: anticentromere

A

CREST scleroderma (limited)

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31
Q

Name the disease: Anti-desmosome (anti-desmoglein)

A

pemphigus vulgaris

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32
Q

Name the disease: Anti-dsDNA

A

SLE

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33
Q

Name the disease: Anti-Smith

A

SLE

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34
Q

Name the disease: Anti-glutamic acid decarboxylase (GAD-65)

A

Type 1 DM

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35
Q

Name the disease: Anti-hemidesmosome

A

Bullous pemphigoid

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36
Q

Name the disease: Anti-histone

A

Drug induced lupus

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37
Q

Name the disease: Anti-Jo-1

A

polymyositis/dermatomyositis

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38
Q

Name the disease: Anti-microsomal

A

Hashimoto thyroiditis

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39
Q

Name the disease: Anti-thyroglobulin

A

hashimoto thyroiditis

40
Q

Name the disease: Antimitochondrial

A

Primary biliary cirrhosis

41
Q

Name the disease: Antinuclear

A

SLE (nonspecific)

42
Q

Name the disease: Anti-parietal cell

A

Pernicious anemia

43
Q

Name the disease: Anti-SSA

A

Sjoren Syndrome

44
Q

Name the disease: Anti-SSB

A

Sjrogen syndrome

45
Q

Name the disease: Anti-SCL 70

A

Scleroderma

46
Q

Name the disease: Anti-DNA topoisomeriase 1

A

scleroderma

47
Q

Name the disease: Anti-smooth muscle

A

autoimmune hepatitis

48
Q

Name the disease: Anti-TSH receptor

A

Graves disease

49
Q

Name the disease: Anti-Ro/Anti-La

A

Sjrogen Syndrome

50
Q

Name the disease: Anti-U1 RNP

A

Mixed connective tissue disease

51
Q

Name the disease: IgA anti-endomysial

A

Celiac

52
Q

Name the disease: anti-tissue transglutaminase

A

Celiac

53
Q

Name the disease: anti-CCP

A

Rheumatoid arthritis

54
Q

Name the disease: p-ANCA

A

microscopic polyangiitis, Churg strauss

55
Q

Name the disease: c-ANCA

A

Wegners granulomatosis

56
Q

Alemtuzumab MOA and clinical use

A

Targets cd52

used for CLL

57
Q

Bevacizumab MOA and clinical use

A

Targets VEGF

Used for colorectal cancer and renal cell carcinoma

58
Q

Cetuximab MOA and clinical use

A

Targets EGFR

Used for stage IV colorectal cancer, head and neck cancer

59
Q

Rituximab MOA and clinical use

A 
Targets CD20 (lyses B cells)
Used for B cell non-Hodgkins lymphoma, CLL, RA, ITP
60
Q

Tratuzumab MOA and clinical use

A

Targets HER2/Neu

Used for breast cancer

61
Q

Adalimumab MOA and clinical use

A

Targets soluble TNF-alpha

Used in IBD, RA, ankylosing spondylitis, psoriasis

62
Q

Infliximab MOA and clinical use

A

Tarets soluble TNF alpha

USed in IBD, RA, ankylosing spondylitis, psoriasis

63
Q

Eculizumab MOA and clinical use

A

Targets complement protein C5

Used for PNH

64
Q

Natalizumab MOA and clinical use

A

Target alpha4 integrin –> WBC adhesion molecule
USed in MS, Crohns
SIDE EFFECT: risk of pML in patients with JC virus

65
Q

Abciximab MOA and clinical use

A

Targets platelet glycoprotein IIb/IIIa
USed as an antiplatelet agent for prevention of ischemic complications in patients undergoing percutaneous coronary intervention

66
Q

Denosumab MOA and clinical use

A

Targets RANKL

Used in osteoporosis to inhibit osteoclast maturation

67
Q

Antidote for digoxin toxicity

A

digoxin Fab immune fab

68
Q

Omalizumab MOA and clinical use

A

Targets IgE

Used in allergic asthma, prevents IgE binding to FceRI

69
Q

Palavizumab MOA and clinical use

A

Targets RSV F protein

RSV prophylaxis for high risk infants

70
Q

Ranibizumab MOA and clinical use

A

targets VEGF

used for neovascular age related macular degeneration

71
Q

Bevacizumab MOA and clinical use

A

targets VEGF

used for neovascular age related macular degeneration

72
Q

Cyclosporine MOA

A

Calcineurin inhibitor - binds cyclophilin - blocks T cell activation by preventing IL-2 transcription

73
Q

Cyclosporine Side effects

A

nephrotoxicity, hypertension, neurotoxicity, gingival hyperplasia, hirsutism

74
Q

Tacrolimus MOA

A

Calcineurin inhibitor - binds FK506 binding protein (FKBP) to prevent IL-2 transcription thus blocking T cell activation

75
Q

Tacrolimus Side effects

A

neurotoxicity, nephrotoxic but no gingival hyperplasia or hirsutism

76
Q

Sirolimus (rapamycin) MOA

A

mTOR inhibitor - also binds FKBP - blocks T and B cell activation/differentiation by preventing response to IL-2

77
Q

Cyclosporine has synergistic effect with which drug

A

sirolimus

78
Q

Daclizumab MOA

A

monoclonal antibodies that block iL-2r

79
Q

Basiliximab moa

A

monoclonal antibodies that block IL-2R

80
Q

azathioprine MOA

A

blocks lymphocyte proliferation by blocking nucleotide synthesis

81
Q

azathioprine side effects

A

bone marrow supression (leukopenia, anemia, thrombocytopenia)

82
Q

azathiprine is metabolized by what

A

XO

83
Q

Glucocorticoids MOA

A

inhibit NFKB, suppress both b and t cell function by decreasing transcription of many cytokines

84
Q

mycophenolate moa

A

inhibits IMP dehydrogenase and thus inhibits guanine synthesis - prevents lymphocyte proliferation

85
Q

thalidomide moa

A

supresses TNF alpha production, increases NK cells and IL-2 - used in erythema nodosum leprosy (hansens)

86
Q

Aldesleukin

A

il-2, used in RCC and metastatic melaonoma

87
Q

Epoetin alfa

A

erythropoietin -anemia, esp. if in renal failure

88
Q

filgrastim

A

G-CSF (recovery of bone marrow)

89
Q

sargramostim

A

GM-CSF recovery of bone marrow

90
Q

IFN alpha used in

A

chronic hep B and C, kaposi, malinant melanoma, hairy cell leukoemia

91
Q

IFN beta used in

A

MS

92
Q

ifn gamma used in

A

chronic granulomatous disorder

93
Q

romiplostim

A

used in thrombocytopenia

94
Q

eltrombopag

A

thrombocytopenia

95
Q

oprelvekin

A

IL-11 also thrombocytopenia

STEP 1 (26 decks)

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