TCA CYCLE

Question 1

Which product of TCA cycle is used for HEME SYNTHESIS ?

Answer 1

Succinyl CoA

Question 2

What are the irreversible steps of TCA cycle ?

Answer 2

Acteyl CoA to Citrate (Citrate Synthase)

Isocitrate to Alpha keto glut (Isocitrate Dehydrogenase)

Aplha keto glut to succinyl CoA (Aplha kgd)

Question 3

Which of the reactions in TCA cycle produces NADH?

Answer 3

Isocitrate to Alpha keto glut
Alpha keto glut to succinyl CoA
Malate to Oxaloacetate

Question 4

Rate limiting step of TCA cycle ?

Answer 4

Isocitrate to Alpha keto glut
(ISOCITRATE DEHYDROGENASE)

Question 5

Reaction that produces ATP/GTP? In TCA

Answer 5

Cleavage of Succinyl COA to Succinate

Question 6

What are the 3 regulatory enzymes of TCA?

Answer 6

Citrate Synthase
Isocitrate Dehydrogenase (RTE)
Alpha keto glut Dehydrogenase

Question 7

How is citrate Synthase inhibited ?

Answer 7

BU it’s own product Citrate

Question 8

Inhibitors of Isocitrate Dehydrogenase ?

Answer 8

ATP
NADH
APLHA KETO GLUTARATE

Question 9

Inhibitors of Alpha keto glutarate Dehydrogenase ?

Answer 9

Succinyl CoA
NADH

Question 10

Which drug inhibits Aconisate and reacts with Acetyl CoA?

Answer 10

Fluoroacetate (RAT POISON)

Question 11

Which drug inhibits Alpha keto glut Dehydrogenase

Answer 11

ARSENITE

Question 12

Which drug inhibits Succinate Dehydrogenase ?

Answer 12

MALONATE