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MCB BLOCK 3 > Glycolysis > Flashcards

Glycolysis Flashcards

1
Q

What is the rate limiting enzyme in glycolysis ?

A

Phosphofructose kinase 1

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2
Q

Reaction in glycolysis that produces ATP ?

A

1,3 BPG to 3PG (Phosphoglycerate kinase)
Phosphoenolpyruvate to Pyruvate (Pyruvate kinase)

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3
Q

Which enzyme catalyses 2-Phosphoglycerate to Phosphoenol Pyruvate ?

A

Enolase

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4
Q

Only reaction in Glycolysis to produce NADH ?

A

Glyceraldehyde-3-phosphate to 1,3 Phosphoglycerate (G3PD)

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5
Q

NET PRODUCTION OF ATP IN GLYCOLYSIS ?

A

2 ATP

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6
Q

3 regulatory enzymes of Glycolysis ?

A

Glucokinase
Phosphofruckotikinase 1
Pyruvate kinase

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7
Q

Activators of glucokinase ?

A

Insulin
ATP
Glucose

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8
Q

Phosphofrucktokinase 1 stimulators ?

A

ADP
Fructose 2,6-bisphosphate (Most powerful regulator)
Insulin

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9
Q

Inhibitors of Posphofrucktokinase 2 ?

A

Glucagon
ATP
CITRATE

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10
Q

Pyruvate kinase inhibitors ?

A

ATP, ARSENATE, ACETYL COA, GLUCAGON

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11
Q

Stimulators of Pyruvate kinase

A

Insulin
Fructose 1,6 Biphosphate (Feedforward mechanism)

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12
Q

Enolase inhibitor ?

A

Fluoride

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13
Q

Inhibitors of G3PD

A

Iodoacetate
Methymercuric chloride

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14
Q

What does Arsenic poisoning inhibits ?

A

PDH complex and alpha ketoglutarate complex

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15
Q

Clinical features of Arsenic poisoning ?

A

Dermatitis
GI distress
Plan to palmar keratosis
Melanesia (Raindrop pigments)
Blackfoot disease (Peripheraal vascular disease)

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16
Q

Pyruvate kinase deficiency CF?

A

Anemia
Splenomegaly
Jaundice
Gall stones

17
Q

Whar is glycolysis ?

A

Process of breaking glycogen

MCB BLOCK 3 (19 decks)

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