OXYGEN TOXICITY AND FREE READ INJURY

Question 1

What are the protecting antioxidant enzymes from free radicals ?

Answer 1

Antioxidant scavenging enzymes
➢ Superoxide dismutase
➢ Catalase
➢ Glutathione reductase
➢ Glutathione peroxidase

Question 2

What are the sources of free radicals ?

Answer 2

Coenzyme Q
• Cytochrome P450 (Liver)
• XDH/oxidase reperfusion injury
• Ionizing radiation
• Phagocytosis (oxygen-dependent killing)

Question 3

What does alcohol inhibit in liver ?
FREE RAD

Answer 3

CytochromeP450

Question 4

On what conditions does Co-q produce ROS?

Answer 4

When mitochondria does not produce ATP
when high NADH/NAD+ ratio.

Question 5

What is it called when neutrophils and macrophages increase free radicals to destroy infectious agent ?

Answer 5

RESPIRATORY BURTS

Question 6

What are the enzymes involved in RESPIRATORY BURST ?

Answer 6

NADPH OXIDASE
MYLO PEROXIDASE

Question 7

What type of bacterias can overcome respiratory Burts by utilizing the free radicals ?

Answer 7

Catalase positive bacterias

Question 8

What are the features of NADPH DEFICIENT Chronic Granulomatous disease ?

Answer 8

X LINKED
YOUNG MALES OFTEN
RECURRING INFECTIONS
NEGATIVE NBT TEST
POSITVE DHR TEST

Question 9

What are the features of Myeloperoxidase DEFICIENT Chronic Granulomatous disease ?

Answer 9

AR
Positive NBT TEST
Positive DHR TEST
RECURRING PENOUMINA OR INFECTIONS