Pyruvate Metabolism Flashcards
Pyruvate to lactic acid cofactor ?
Vitamin B3 Niacin
Pyruvate to alanine cofactor?
Vitamin B6
Pyruvate to Acetyl Coa Cofactors?
The Lovely Coenzyme For Needs
Thiamine phosphate (B1)
Lipoamide
Coenzyme A (B5)
FAD (RIBOFLAVIN)
NADH (NIACIN)
Name the 3 complex of Pyruvate Dehydrogenase.?
Pyruvate Dehydrogenase
Dihydrolipyl Transacetylase
Dihydrolipyl Dehydrogenase
Does phosphorylated PDH an active or inactive enzyme ?
Inactive
What is the cause of lactic acidosis?
Increase in Cori cycle and more lactate.
Decrease in Pyruvate Dehydrogenase
What are the diseases associatied with B1 Thiamine deficiency.?
Werkinke korkoff (Alcoholics)
Dry BER1 BER1 (peripheral nerves)
WET BERI BERI (heart capillaries)
INFANTILE BERI BERI (quiet cry, tachycardia) (B1 Deficient in MOM)
What the enzymes that requires B1 as a cofactor ?
Pyruvate Dehydrogenase
Alpha keto glutarate Dehydrogenase
Branched keto acid Dehydrogenase
Transketolase
What aree the symptoms of Riboflavin (B2)deficiency ?
2C of B2
Chelosis
Corneal Vascularisation
What the enzymes that requires Riboflavin as a cofactor ?
Succinate Dehydrogenase
Acyl CoA Dehydrogenase
NADH Dehydrogenase
Di hydrolipoyl Dehydrogenase
What are the symptoms of NIACIN (B3) Deficiency ? (PHDDD)
Pellegra
HARTNUP
CARCINOID SYNDROME
DIARRHEA
DEMENTIA
DERMATITS