Pyruvate Metabolism

Question 1

Pyruvate to lactic acid cofactor ?

Answer 1

Vitamin B3 Niacin

Question 2

Pyruvate to alanine cofactor?

Answer 2

Vitamin B6

Question 3

Pyruvate to Acetyl Coa Cofactors?

Answer 3

The Lovely Coenzyme For Needs

Thiamine phosphate (B1)
Lipoamide
Coenzyme A (B5)
FAD (RIBOFLAVIN)
NADH (NIACIN)

Question 4

Name the 3 complex of Pyruvate Dehydrogenase.?

Answer 4

Pyruvate Dehydrogenase
Dihydrolipyl Transacetylase
Dihydrolipyl Dehydrogenase

Question 5

Does phosphorylated PDH an active or inactive enzyme ?

Answer 5

Inactive

Question 6

What is the cause of lactic acidosis?

Answer 6

Increase in Cori cycle and more lactate.
Decrease in Pyruvate Dehydrogenase

Question 7

What are the diseases associatied with B1 Thiamine deficiency.?

Answer 7

Werkinke korkoff (Alcoholics)
Dry BER1 BER1 (peripheral nerves)
WET BERI BERI (heart capillaries)
INFANTILE BERI BERI (quiet cry, tachycardia) (B1 Deficient in MOM)

Question 8

What the enzymes that requires B1 as a cofactor ?

Answer 8

Pyruvate Dehydrogenase
Alpha keto glutarate Dehydrogenase
Branched keto acid Dehydrogenase
Transketolase

Question 9

What aree the symptoms of Riboflavin (B2)deficiency ?

2C of B2

Answer 9

Chelosis
Corneal Vascularisation

Question 10

What the enzymes that requires Riboflavin as a cofactor ?

Answer 10

Succinate Dehydrogenase
Acyl CoA Dehydrogenase
NADH Dehydrogenase
Di hydrolipoyl Dehydrogenase

Question 11

What are the symptoms of NIACIN (B3) Deficiency ? (PHDDD)

Answer 11

Pellegra
HARTNUP
CARCINOID SYNDROME
DIARRHEA
DEMENTIA
DERMATITS