Hmp Pentose Pathway Flashcards

1
Q

What are the two stages of HMP PATHWAY ?

A

IR OXIDATIVE (G6P TO RIBULOSE 5P)

REVER NON OXIDATIVE (RIBULOSE 5P TO FRUCTOSE 6 P or GLYCERALDEHYDE 3P)

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2
Q

What are the enzymes involved in hmp shunt ?

A

Oxidative - G6PD
Non Oxid - Transketolase (2c) and Transaldolase (3c)

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3
Q

Why do Erythrocytes use Glutathione ?

A

To overcome oxidative damage

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4
Q

What is Transketolase used for?

A

To asess B1 thiamine level to diagnose BERI BERI

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5
Q

What is the cause of G6PD deficiency ?
(sub African and sub east Asian)
IMPORTANT

A

Triggered when exposed to oxidant drugs like antimalarial drug and FAVA BEANS

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6
Q

What are the clinical presentation of G6PD deficiency ?

A

Anemia
Jaundiced sclera
LOW HEMATOCRIT (IMPORTANT)
HIGH SERUM BILURUBIN (IMPORTANT)
HEINZ BODIES (IMPORTANT)
BITE CELLS (IMPORTANT)

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