Hmp Pentose Pathway Flashcards
1
Q
What are the two stages of HMP PATHWAY ?
A
IR OXIDATIVE (G6P TO RIBULOSE 5P)
REVER NON OXIDATIVE (RIBULOSE 5P TO FRUCTOSE 6 P or GLYCERALDEHYDE 3P)
2
Q
What are the enzymes involved in hmp shunt ?
A
Oxidative - G6PD
Non Oxid - Transketolase (2c) and Transaldolase (3c)
3
Q
Why do Erythrocytes use Glutathione ?
A
To overcome oxidative damage
4
Q
What is Transketolase used for?
A
To asess B1 thiamine level to diagnose BERI BERI
5
Q
What is the cause of G6PD deficiency ?
(sub African and sub east Asian)
IMPORTANT
A
Triggered when exposed to oxidant drugs like antimalarial drug and FAVA BEANS
6
Q
What are the clinical presentation of G6PD deficiency ?
A
Anemia
Jaundiced sclera
LOW HEMATOCRIT (IMPORTANT)
HIGH SERUM BILURUBIN (IMPORTANT)
HEINZ BODIES (IMPORTANT)
BITE CELLS (IMPORTANT)
