Alcohol Metabolism

Question 1

What are the three steps of alcohol Metabolism ?

Answer 1

Ethanol
Acetaldehyde
Acetate

Question 2

What is microsomal ethanol oxidasing system ?

Answer 2

Second route of ethanol Metabolism
Ethanol to Acetaldehyde
Increases ROS

Question 3

What does phenobarbital (sleeping pills induce) regarding to alcohol Metabolism ?

Answer 3

Induces RESISTANCE TO DRUG AND INCREASES OXIDATIVE ENZYMES

Question 4

What are the energy yield of ethanol oxidation by ALDH and MEOS?

Answer 4

ADH, ALDH = 2 NADH (2*2.5ATP)
MEOS, ALDH = 1 NADH (2.5 ATP)

Question 5

What is hyperuricemia?

Answer 5

Competition between uric and lactic acid for excretion in alcholics

Question 6

What are the toxic effects of ethanol Metabolism ?

Answer 6

High NADH
TCA CYCLE INHIBITON
INCREASES ACETYL COA (TCA INHIBITON)
Excess ketone body formation
LACTIC ACIDOSIS
HYPERURICEMIA
HYPOGLYCEMIA

Question 7

What are the symptoms of methanol poisoning ? (Windshield fluid, moonshine)

Answer 7

Retinal injury
Optic disc hyperemia
Edema
Permanant blindness
Mitochondrial disfunction

Treatment - Ethanol

Question 8

What are the symptoms of ethylene glycol poisoning ? (Antifreeze, polyester fibres)

Answer 8

Acute renal failure - oxalate crystals

Question 9

What are the drugs used to treat ethanol Metabolism ?

Answer 9

Fomepizide
Disulfrum