TB Drugs Flashcards
MOA of rifamycins
inhibit DNA dependent RNA polymerase
what is rifamycins used for
- TB
- HFLU and all meningitis prophylaxis
What are the four Rs of rifamycins
- RNA polymerase inhibitor
- ramps up P450
- red orange body fluids
- rapid resistance if used alone
MOA of isoniazid
dec synthesis of mycolic acids
bacterial catalase - KatG - needs to convert to active
describe the toxicity of Isoniazid
INH = Neuro and hepato
how can you prevent neurotoxicity with isoniazid
pyrimidine
What is the MOA and s/e of ethambutol?
MOA: dec carb polym - inhibit arabinosyltransferase
s/e: optic neuropathy
What is ceftriaxone used for
- meningitis
- gonorrhea
- disseminated lyme disease
What would you use for a STD infection with presumed gonorrhea
ceftriaxone + azithromycin or doxy for chlamydia
What does chloramphenicol treat
all meningitis causes
rocky mountain fever
What are the s/e of chloramphenicol
gray baby syndrome
anemia -dose dependent
What drug do you use for high risk endocarditis
amoxicillin
What are the prophylactic drugs for HIV and what/ when are they used?
- <50 azithromycin or clarithromycin for MAC
What is the MOA of terbinafine, what is it used for
inhibits squalene epoxidase
treats dermatophytoses
MOA and use of griseofulvin
interferes with MT function
treats dermatophytes
