Respiratory Flashcards
name the first gen H1 antagonists
diphenhydramine
dimenhydrinate
chlorpheniramine
what are the second gen h1 antagonists, how are they different?
loratadine
fexofenadine
desloratadine
cetirizine
-less sedating - dont cross BBB
What is the name of the expectorant that thins resp secretions
guaifenesin
how does N-acetylcysteine work for CF patients
disrupts disulfide bonds - mucolytic
MOA of detromethorphan
inhibits NMDA glutamate
What are some complications of dextromethorphan use
OD - use naloxone
serotonin syndrome
what are the alpha adrenergic agonists used to treat nasal congestion
pseudoephedrine
phenylephrine
MOA of bosentan? use?
endothelin 1 antagonist - treats pulm htn
A physician cannot tell if a patient has asthma. What drug could be used in an asthma challenge test for this patient?
metacholine
A patient wants to try theophylline, but is worried about side effects. What two side effects do you counsel the patient on?
Cardiotoxicity and neurotoxicity
what are the long acting B2 agonists
salmeterol formoterol
What is the first line treatment for chronic asthma
fluticasone and budesonide - corticosteroids
What is an antiIgE ab used in allergic asthma
omalizumab
what is the MOA if ipatropium
blocks muscarinic Ach
MOA of theophylline?
blocks phosphodiesterase - inhibits cAMP breakdown
also blocks adenosine
allows for bronchodilation
