Autonomics 1 Flashcards
To what class of G proteins are α1, α2, β1, & β2 receptors linked?
Q, I , S, S (kiss)
To what class of G proteins are M1, M2, and M3 receptors linked?
Q, I , Q - kick
To what class of G proteins are D1, D2, and H1 receptors linked?
S, I, Q - sick
What are the major effects of α1-receptor activation?
- vasoconstriction
- bladder contraction
- intestinal contraction
- pupil dilatory muscle contraction
What are the major functions of α2-receptor activation?
- decreases sympathetic output
- decreases insulin production
- decreases lipolysis
- increases platelet aggregation
What are the major functions of β1-receptor activation?
It increases heart rate and contractility,
increases renin release, lipolysis of adipose tissue
What is the major function of β2-receptor activation ?
vasodilation
bronchodilation
decrease uterine tone - tocolysis
Where are M1 receptors located?
CNS
enteric nervous
What effect does M2-receptor activation have?
decrease contractility and HR of atria
what does M3 do
increases exocrine gland secretions
inc bladder contraction
bronchoconstriction
inc pupillary muscle contraction - miosis
ciliary muscle contraction - accomodation
What neurotransmitter/receptor mediates sympathetic nervous system function at the sweat glands?
acetylcholine - muscarinic
What effect does D1-receptor activation have on renal vasculature?
relaxation
What are the effects of H1-receptor activation?
Pruritus, pain, nasal & bronchial mucus production, contraction of bronchioles, increase vascular permeability
What is the effect of V2-receptor activation? Where are they located?
Increases water permeability and reabsorption in the collecting tubules of the kidney (V2 is found in the 2 kidneys)
What is the function of V 1?
vascular smooth muscle contraction
