Repro Flashcards
Leuprolide MOA, use
GnRH anlog
pulsatile: infertility
continuous: prostate cancer, fibroids, precocious puberty
What drug is known to cause clear cell vaginal adenocarcinoma in children of pregnant mothers who receive it
DES
moa of clomiphene
estrogen antagonist in hypothalamus
inc release of LH and FSH from the pituitary via feedback
stimulates ovulation
list the antagonist and agonist properties of tamoxifene and raloxifene
tamoxifene
antagonist: breast, agonist: uterus, bone
raloxifene
antagonist: breast, uterus , agonist: bone
what are the aromatase inhibitors, what are they used for
anastrozole, exemestane
used in postmenopausal women with ER+ breast cancer
function of progestins
dec growth and inc vascularization of the endometrium
what are the abortion drugs
mifepristone inhibits progestin and misoprostol - PGE1
how does birth control work
estrogen and progestin inhibit LH and FSH
prevent estrogen surge -> no LH surge –> no ovulation
aslo progestin allows for cervical mucus production
MOA and use of terbutaline and ritodrine
B2 agonists that relax the uterus - dec contraction frequency
MOA and use of danazol
synthetic androgen
used for endometriosis and hereditary angioedema
Finasteride MOA and use
blocks 5a reductase - dec DHT production
BPH and male pattern baldness
flutamide MOA and use
competitive inhibitor of androgen
used for prostate carcinoma
What drugs treat PCOS androgenic symptoms
ketoconazole and spironolactone
Tamsulosin MOA and use
alpha1 antagonist
treats BPH - inhibits SM contraction
What drugs are used to treat erectile dysfunction by inhibitng PDE5
“fil”s - sildenafil, vardenafil, tadalafil
