Heme / Onc 2

Question 1

6mp / 6tg

1. Action
2. activated by
3. inactivated by

Answer 1

1. dec de novo purine synthesis
2. activated by HGPRT
3. Inactivated by XO

Question 2

What drugs inc toxicity with 6 mP

Answer 2

Allopurinol and febuxostat - inhibit XO

Question 3

What is the drug of choice for AML

Answer 3

cytarabine

Question 4

MOA of 5FU

Answer 4

Converted to 5FdUMP and blocks TS

Question 5

Which drug is reversible by leucovorin - 5 FU or Methotrexate

Answer 5

methotrexate only!!!

Question 6

What are some toxicities of methotrexate

Answer 6

hepatotoxicity
pulm fibrosis
mouth ulcers
myelosuppression

Question 7

What are the MT inhibitors - MOA and what they are used for

Answer 7

1. paclitaxel, taxols - hyperstabilize polymerized MTs
   ovarian and breast carcinoma

both inhibit polymerization:

2. vincristine -non-hodkins
3. vinblastine - hodkins

Question 8

what is the main toxicity of MT inhibitors

Answer 8

neurotoxicity

Question 9

What is the main s/e of cisplatin? what can you do to prevent this?

Answer 9

nephrotoxicity - give amifostine

Question 10

MOA of etoposide/ teniposide

Answer 10

inhibit topo II - inc + and negative supercoiling

Question 11

what is etoposide used to treat

Answer 11

testicular and small cell lung cancer

Question 12

MOA of irinotectan and what is it used to treat

Answer 12

inhibits topo I -inc negative supercoiling

treats colon cancer

Question 13

Hydroxyurea is specific for what phase of the DNA cycle

Answer 13

S phase

Question 14

what is hydroxyurea used for

Answer 14

melanoma, CML, sickle cell disease

Question 15

name the VEGF inhibitor used to treat solid tumors

Answer 15

bevacizumab

Question 16

what does erlotinib block

Answer 16

EGFR

Question 17

what is erlotinib used to treat

Answer 17

non- small cell lung carcinoma

Question 18

What drug has revolutionized CML treatment

Answer 18

imatinib

Question 19

what drug inhibits CD20

Answer 19

rituximab

Question 20

what is the main s/e of rituximab

Answer 20

PML

Question 21

does tamoxifen or raloxifene inc risk of endometrial cancer

Answer 21

tamoxifen only

raloxifene is an estrogen antagonist in endometrial tissue

Question 22

what is raloxifene also used for

Answer 22

osteoporosis

Question 23

trastuzumab is used to treat

Answer 23

HER2

Question 24

what is the toxicity of trastuzumab

Answer 24

cardiotoxicity

Question 25

MOA of vemurafenib and toxicity

Answer 25

BRAF oncogene - blocks

used to treat melanoma