Heme / Onc 2 Flashcards
6mp / 6tg
- Action
- activated by
- inactivated by
- dec de novo purine synthesis
- activated by HGPRT
- Inactivated by XO
What drugs inc toxicity with 6 mP
Allopurinol and febuxostat - inhibit XO
What is the drug of choice for AML
cytarabine
MOA of 5FU
Converted to 5FdUMP and blocks TS
Which drug is reversible by leucovorin - 5 FU or Methotrexate
methotrexate only!!!
What are some toxicities of methotrexate
hepatotoxicity
pulm fibrosis
mouth ulcers
myelosuppression
What are the MT inhibitors - MOA and what they are used for
- paclitaxel, taxols - hyperstabilize polymerized MTs
ovarian and breast carcinoma
both inhibit polymerization:
- vincristine -non-hodkins
- vinblastine - hodkins
what is the main toxicity of MT inhibitors
neurotoxicity
What is the main s/e of cisplatin? what can you do to prevent this?
nephrotoxicity - give amifostine
MOA of etoposide/ teniposide
inhibit topo II - inc + and negative supercoiling
what is etoposide used to treat
testicular and small cell lung cancer
MOA of irinotectan and what is it used to treat
inhibits topo I -inc negative supercoiling
treats colon cancer
Hydroxyurea is specific for what phase of the DNA cycle
S phase
what is hydroxyurea used for
melanoma, CML, sickle cell disease
name the VEGF inhibitor used to treat solid tumors
bevacizumab
what does erlotinib block
EGFR
what is erlotinib used to treat
non- small cell lung carcinoma
What drug has revolutionized CML treatment
imatinib
what drug inhibits CD20
rituximab
what is the main s/e of rituximab
PML
does tamoxifen or raloxifene inc risk of endometrial cancer
tamoxifen only
raloxifene is an estrogen antagonist in endometrial tissue
what is raloxifene also used for
osteoporosis
trastuzumab is used to treat
HER2
what is the toxicity of trastuzumab
cardiotoxicity
MOA of vemurafenib and toxicity
BRAF oncogene - blocks
used to treat melanoma
