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Pharmacology Shelf > Endocrine > Flashcards

Endocrine Flashcards

1
Q

What agent do you give for DKA?

A

IV regular insulin

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2
Q

What are the s/e of metformin?

A

GI upset

Lactic acidosis - can’t use in renal insufficiency

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3
Q

What are the first generation sulfonylureas

A

chlorporpamide

tolbutamide

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4
Q

What is the main s/e of first gen sulfonylureas

A

disulfiram like effect

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5
Q

what are the second gen sulfonylureas

A

glimepiride
glipizide
glyburide

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6
Q

what is the main s/e of second gen sulfonylureas

A

hypoglycemia

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7
Q

What oral agents cause hypoglycemia

A

pramlintide
sulfonylureas
insulin

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8
Q

What are the glitazones or thiazolidinediones

A

pioglitazone

rosiglitazone

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9
Q

What are the GLP1 analogs? what is the main s/e

A

exenatide
liraglutide

nausea/vomiting pancreatitis

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10
Q

What are the DPP4 inhibitors

A

“gliptins”

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11
Q

What is the function of pramlintide

A

dec gastric emptying

dec glucagon

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12
Q

What are the SLGT2 inhibitors? how do they work?

A

canaglifozin

block reabsorption of glucose in PCT

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13
Q

what are the alpha glucosidase inhibitors

A

acarbose

miglitol

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14
Q

Which hyperthyroid medication should be used in pregnancy?

A

propylthiouracil

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15
Q

What are the ADH antagonists used for SIADH

A

conivaptan and tolvaptan

demeocycline

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16
Q

What is desmopressin used for

A

central DI

also used in vWF disease !

17
Q

How do glucocorticoids work

A

block phospholipase A2

inhibit transcription of NFkB

18
Q

What is cinacalcet

A

sensitizes ca2+ sensing receptor - dec PTH

19
Q

what diabetes drug can cause weight gain

A

glitazones

20
Q

what functional tests do you need to measure before administering glitazones

A

LFTs - can cause hepatotoxicity

21
Q

what are the uses of somatostatin (ocreotide)

A 
acromegaly
carcinoid syndrome
gastrinoma
glucagonoma
esophageal varices

Pharmacology Shelf (17 decks)

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