Endocrine Flashcards
What agent do you give for DKA?
IV regular insulin
What are the s/e of metformin?
GI upset
Lactic acidosis - can’t use in renal insufficiency
What are the first generation sulfonylureas
chlorporpamide
tolbutamide
What is the main s/e of first gen sulfonylureas
disulfiram like effect
what are the second gen sulfonylureas
glimepiride
glipizide
glyburide
what is the main s/e of second gen sulfonylureas
hypoglycemia
What oral agents cause hypoglycemia
pramlintide
sulfonylureas
insulin
What are the glitazones or thiazolidinediones
pioglitazone
rosiglitazone
What are the GLP1 analogs? what is the main s/e
exenatide
liraglutide
nausea/vomiting pancreatitis
What are the DPP4 inhibitors
“gliptins”
What is the function of pramlintide
dec gastric emptying
dec glucagon
What are the SLGT2 inhibitors? how do they work?
canaglifozin
block reabsorption of glucose in PCT
what are the alpha glucosidase inhibitors
acarbose
miglitol
Which hyperthyroid medication should be used in pregnancy?
propylthiouracil
What are the ADH antagonists used for SIADH
conivaptan and tolvaptan
demeocycline
What is desmopressin used for
central DI
also used in vWF disease !
How do glucocorticoids work
block phospholipase A2
inhibit transcription of NFkB
What is cinacalcet
sensitizes ca2+ sensing receptor - dec PTH
what diabetes drug can cause weight gain
glitazones
what functional tests do you need to measure before administering glitazones
LFTs - can cause hepatotoxicity
what are the uses of somatostatin (ocreotide)
acromegaly carcinoid syndrome gastrinoma glucagonoma esophageal varices
