GI drugs Flashcards
What are the H2 blockers
“tidines” - cimetidine, ranitidine etc
what are the s/e of cimetidine
inhibits P450
antiandrogenic effects
crosses the bbb and can cause confusion, headaches
dec excretion of creatinine (so does ranitidine)
MOA of the proton pump inhibitors
inhibits H/K ATPase in parietal cells
what are the s/e of the proton pump inhibitors
inc risk of C diff
dec serum Mg2+
What is the only drug that treats NSAID induced ulcers
misoprostol - PGE1 analog
besides ulcers what else does misoprostol treat
maintenance of a PDA
ripening the cervix
MOA of ocreotide
somatostatin analog
use of ocreotide
acute variceal bleeds
acromegaly
VIPoma
carcinoid tumors
antacids are notorious for what
decreasing the absorption and bioav of drugs
also cause hypokalemia
what are some specific s/e of the antacids
- aluminum hydroxide - constipation, low P
- calcium carbonate - rebound acidity
- magnesium hydroxide - diarrhea
name the osmotic laxatives
magnesium hydroxide
magnesium citrate
polyethylate glycol
lactulose
what is special about lactulose
also treats hepatic encephlopathy - helps promote nitrogen excretion
MOA of sulfasalazine
sulfapyridine + 5 aminosalicylic acid activated by colonic bacteria
MOA of ondansetron
5HT3 antagonist
dec vagal stimulation
central acting anti emetic
s/e of ondansetron
headache, constipation, in QT interval
