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Pharmacology Shelf > MSK > Flashcards

MSK Flashcards

1
Q

What PG inhibits platelet aggregation? what med blocks this?

A

PGI2

epoprostenol - pulmonary hypertension

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2
Q

What PG increases uterine tone? what meds block them?

A

PGE2 - Dinoprostone - cervical ripening

PGF2
carboprost - abortifacent
latanoprost - glaucoma

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3
Q

What is the MOA of montelukast?

A

leukotriene receptor antagonist

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4
Q

What med blocks lipoxygenase and therefore leukotriene synthesis?

A

Zileuton

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5
Q

What drug only blocks COX2?

A

cecoxib

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6
Q

What is the role of TXA2

A

inc platelet aggregation

inc vascular tone

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7
Q

What is the function of LTB4?

A

neutrophil chemotactic

“neutrophils arrive B4 the others”

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8
Q

What luekotrienes inc bronchial tone

A

LTC, D, E4

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9
Q

How does acetaminophen differ from NSAIDs?

A

NOT antiinflammatory

inactivated peripherally

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10
Q

How does aspirin affect PT/ PTT?

A

it does NOT

it inc bleeding time however by inhibiting TXA2 synth

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11
Q

Describe what the different doses of acetaminophen are good for:

  1. low
  2. intermediate
  3. high
A

low - antiplatelet
medium - antipyretic, analgesic
high - anti inflammatory

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12
Q

What cranial nerve does aspirin have an effect on?

A

CNVIII - tinnitus

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13
Q

What is misoprostol?

A

analog of PGE1 used to treat NSAID induced ulcers

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14
Q

What other drug blocks PGE1? Use?

A

alprostadil - mantains patency of PDA

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15
Q

What drug is used to close a patent PDA?

A

indomethacin

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16
Q

What are the s/e of celecoxib

A

thrombosis - inhibits endothelial function

sulfa allergy!!!

17
Q

MOA of bisphosphonates?

A

bind hydroxyapetite in bone - inhibit osteoclasts

18
Q

What is teriparatide?

A

recombinant PTH analog - inhibits osteoblasts

19
Q

What do you give in asprin hypersensitivity

A

montelukast

20
Q

MOA of allopurinol

A

inhibits XO - dec purine metabolism

21
Q

What drug concentrations are inc with allopurinol use

A

azathioprine

6 MP

22
Q

MOA of probenecid

A

inhibits reabsorption of uric acid in PCT

23
Q

What does probenecid block the secretion of

A

penicillins, cephalosporins, fluoroquinolones

24
Q

MOA of colchine

A

prevents tubulin polym –I PMN chemotaxis

25
Q

What med is contraindicated in Gout?

A

aspirin - depresses uric acid clearance

26
Q

MOA of etanercept?

A

fusion of TNF alpha + IgG Fc

etanerCEPT is a TNF decoy reCEPTor

27
Q

What are the anti TNF alpha monoclonal abs?

A

infliximab

adalimumab

28
Q

What RA drugs cant be given in G6PD

A

hydrochloroquine

sulfasalazine

Pharmacology Shelf (17 decks)

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