TB

Question 1

T/F TB can affect any organ, not just the lungs

Answer 1

True

Question 2

MTB has a ___ cell envelope

Answer 2

waxy

Question 3

define Multidrug Resistant Mtb (MDR-TB)

Answer 3

a strain resistant to both

isoniazid and rifampin.

Question 4

define Extensively Drug Resistant Mtb (XDR-TB)

Answer 4

a strain resistant to isoniazid and rifampin plus any fluoroquinolone and at least one of the injectable second-line agents (amikacin, kanamycin, or capreomycin).

Question 5

isoniazid is used to treat?

Answer 5

TB

Question 6

T/F isoniazid is given in combo with other drugs

Answer 6

True

Question 7

what does isoniazid inhibit?

Answer 7

mycolic acid biosynthesis

Question 8

what enzyme does isoniazid target?

Answer 8

enoyl-acyl carrier protein reductase

Question 9

which drug is the most potent anti-TB agent?

Answer 9

Rifampin

Question 10

does Rifampin have activity towards gram - bacteria?

Answer 10

yes

Question 11

what does Rifampin inhibit?

Answer 11

DNA-dependent RNA polymerase

Question 12

what is Rifabutin primarily used to treat?

Answer 12

M. avium complex

Question 13

what is the main advantage to using Rifapentine over Rifampin?

Answer 13

less frequent dosing

Question 14

what is Rifaximin used for?

Answer 14

treating traveler’s diarrhea

Question 15

T/F Rifaximin is one of the most potent anti-TB agents

Answer 15

False, not used for TB

Question 16

when is Ethambutol used?

Answer 16

in combo with rifampin

Question 17

what does Ethambutol inhibit?

Answer 17

MTB cell wall biosynthesis

Question 18

what enzyme does Ethambutol inhibit?

Answer 18

arabinosyltransferase

Question 19

what does Pyrazinamide inhibit?

where does it bind?

Answer 19

rans-translation in M. tb.

to the ribosomal protein S1

Question 20

identify all the second-line antitubercular drugs

Answer 20

Aminoglycosides 
Ethionamide 
Cycloserine
Aminosalicylic acid
Capreomycin
Fluoroquinolones