Antifolates Flashcards
antifolates are otherwise know as ___ drugs
sulfa
what was the first sulfa drug to successfully treat bacterial infections?
Prontosil
what do antifolates inhibit?
folic acid biosynthesis
solfisoxazole is the most ____ sulfonamide with a pka of ___
acidic, ~5
Sulfacetamide is used to treat?
eye infections
Mupirocin is used for?
skin infections by staph
what does mupirocin inhibit?
protein biosynthesis
Metronidazole is active towards gram +? gram -?
both
what is Metronidazole used to treat?
bacterial vaginosis and parasitic infections, including trichomoniasis and the intestinal parasitic infections giardiasis and amebiasis
Nitrofurantoin is active towards gram +? gram -?
both
what is Nitrofurantoin not active towards?
Proteus, Serratia, and Pseudomonas
spp.
Nitrofurantoin is mainly used to treat?
UTI
T/F Nitrofurantoin can discolor the urine dark yellow or brown
True
