Macrolides Flashcards
what do macrolides bind to?
50S bacterial ribosomal subunit
which specific sRNA do macrolides bind to?
23 sRNA
bactericidal or bacteriostatic?
bacteriostatic
erythromycin A is what class of antibiotic?
macrolide
T/F all second generation macrolides are derivatives of erythromycin A
True
erythromycin A gram -? gram +?
both
azithromycin gram -? gram +?
both, better for gram -, less active against gram +
it effectively treats?
gonorrhea
clarithromycin gram -? gram +?
more active towards both
three mechanisms of Macrolide Resistance?
1) Target Modification
2) Drug Inactivation
3) Active efflux
lincomycin is effective towards what infection?
staph infection
what are the two antibiotics in the lincosamide family?
lincomycin and clindamycin
Linezolid is most active towards which gram + pathogens?
MRSA and VRE
linezolid has some gram - activity towards?
H. influenzae and legionella
does linezolid have activity towards Enterobacteriaceae or Pseudomonas spp.?
No
does linezolid have activity towards Mycobacterium tuberculosis and M. avium complex?
Yes
chloramphenicol is naturally produced from?
streptomyces
which isomer is the naturally occurring one?
a. R,R
b. R,S
c. S,S
d. S,R
R,R
chloramphenicol is sometimes used for what infection?
bacterial meningitis
Retapamulin is an approved topical treatment for?
impetigo caused by staph infection
Fidaxomicin is effective against which bacteria?
clostridium difficile
