Peptides

Question 1

most peptide antibiotics contained _______ amino acids

Answer 1

non-proteinogenic

Question 2

which type of peptide antibiotic inhibits protein biosynthesis?

Answer 2

streptogramins

Question 3

bacitracin antibiotics are produced by?

Answer 3

Bacillus subtilis

Question 4

Bacitracins target gram -? gram +?

Answer 4

only gram +

Question 5

T/F bacitracins are given orally

Answer 5

False, used topically

Question 6

T/F bacitracins are broad spectrum topical

Answer 6

true

Question 7

what does bacitracins inhibit?

Answer 7

peptidoglycan biosynthesis

Question 8

specifically, what enzyme does bacitracin block?

Answer 8

diphosphatase

Question 9

Tricyclic heptapeptide with a disaccharide attached identified from an Amycolatopsis sp. describes what class of antibiotics?

Answer 9

glycopeptides

Question 10

what drug class is vancomycin?

Answer 10

glycopeptides

Question 11

glycopeptides target gram -? gram +?

Answer 11

only gram +

Question 12

T/F vancomycin is given both orally and by IV

Answer 12

true

Question 13

what symptom caused by Clostridium difficile does vancomycin treat when given orally?

Answer 13

diarrhea

Question 14

glycopeptides block production of peptidoglycan by what mechanism of action?

Answer 14

Inhibits both transglycosylation and transpeptidation steps

Question 15

what class of antibiotics is telavancin?

Answer 15

glycopeptide

Question 16

telavancin is a _____ derivative of vancomycin

Answer 16

semisynthetic

Question 17

what is different from telavancin compared to vancomycin?

Answer 17

telavancin has a lipid tail

Question 18

what class of antibiotics is Dalbavancin?

Answer 18

glycopeptide

Question 19

Dalbavancin is used to treat?

a. Clostridium difficile infection
b. Gonorrhea and E. coli
c. ABSSSI including MRSA
d. EHEC and ETEC for diarrhea
e. E. faecalis including E. faecium

Answer 19

c

Question 20

what class of antibiotics is Oritavancin?

Answer 20

glycopeptide

Question 21

Oritavancin is used to treat?

Answer 21

ABSSSI

Question 22

which two common bacterium are Vancomycin Resistant Enterococci (VRE)?

Answer 22

E. faecalis and E. faecium.

Question 23

Van A is resistant to? is susceptible to?

Answer 23

teicoplanin and vancomycin

oritavancin

Question 24

Van B is resistant to? is susceptible to?

Answer 24

vancomycin

teicoplanin

Question 25

Van C is resistant to? is susceptible to?

Answer 25

vancomycin

teicoplanin

Question 26

Which of the following is INCORRECT about VanA and VanB: (P-SLO: TM, 1.1.1)

a. VanA and VanB have the same catalytic (enzymatic) functions
b. The expression of vanA and vanB genes can be induced by vancomycin
c. VanB phenotype VRE is usually susceptible to dalbavancin
d. VanA and VanB can hydrolyze vancomycin

Answer 26

d

Question 27

polymixins/colistins are modified decapeptides isolated from what bacteria strain?

Answer 27

Bacillus polymyxa

Question 28

T/F polymixins/colistins antibiotics can be taken orally

Answer 28

False, only topically

Question 29

polymixins/colistins target gram -? gram +?

Answer 29

only gram -

Question 30

what is polymixins/colistins mechanism of action?

Answer 30

to form a complex with lipid A

Question 31

gramicidins are produced by what bacteria strain?

Answer 31

Bacillus gravis

Question 32

gramicidins target gram -? gram +?

Answer 32

gram +

Question 33

what common topical ointment contains gramicidin?

Answer 33

neosporin

Question 34

T/F gramicidins are only used topically

Answer 34

True

Question 35

what class of antibiotics is Daptomycin?

Answer 35

gramicidin

Question 36

T/F Quinupristin/dalfopristin is given orally

Answer 36

False

Question 37

what drug class is Quinupristin/dalfopristin?

Answer 37

streptogramins