Peptides Flashcards
most peptide antibiotics contained _______ amino acids
non-proteinogenic
which type of peptide antibiotic inhibits protein biosynthesis?
streptogramins
bacitracin antibiotics are produced by?
Bacillus subtilis
Bacitracins target gram -? gram +?
only gram +
T/F bacitracins are given orally
False, used topically
T/F bacitracins are broad spectrum topical
true
what does bacitracins inhibit?
peptidoglycan biosynthesis
specifically, what enzyme does bacitracin block?
diphosphatase
Tricyclic heptapeptide with a disaccharide attached identified from an Amycolatopsis sp. describes what class of antibiotics?
glycopeptides
what drug class is vancomycin?
glycopeptides
glycopeptides target gram -? gram +?
only gram +
T/F vancomycin is given both orally and by IV
true
what symptom caused by Clostridium difficile does vancomycin treat when given orally?
diarrhea
glycopeptides block production of peptidoglycan by what mechanism of action?
Inhibits both transglycosylation and transpeptidation steps
what class of antibiotics is telavancin?
glycopeptide
telavancin is a _____ derivative of vancomycin
semisynthetic
what is different from telavancin compared to vancomycin?
telavancin has a lipid tail
what class of antibiotics is Dalbavancin?
glycopeptide
Dalbavancin is used to treat?
a. Clostridium difficile infection
b. Gonorrhea and E. coli
c. ABSSSI including MRSA
d. EHEC and ETEC for diarrhea
e. E. faecalis including E. faecium
c
what class of antibiotics is Oritavancin?
glycopeptide
Oritavancin is used to treat?
ABSSSI
which two common bacterium are Vancomycin Resistant Enterococci (VRE)?
E. faecalis and E. faecium.
Van A is resistant to? is susceptible to?
teicoplanin and vancomycin
oritavancin
Van B is resistant to? is susceptible to?
vancomycin
teicoplanin
Van C is resistant to? is susceptible to?
vancomycin
teicoplanin
Which of the following is INCORRECT about VanA and VanB: (P-SLO: TM, 1.1.1)
a. VanA and VanB have the same catalytic (enzymatic) functions
b. The expression of vanA and vanB genes can be induced by vancomycin
c. VanB phenotype VRE is usually susceptible to dalbavancin
d. VanA and VanB can hydrolyze vancomycin
d
polymixins/colistins are modified decapeptides isolated from what bacteria strain?
Bacillus polymyxa
T/F polymixins/colistins antibiotics can be taken orally
False, only topically
polymixins/colistins target gram -? gram +?
only gram -
what is polymixins/colistins mechanism of action?
to form a complex with lipid A
gramicidins are produced by what bacteria strain?
Bacillus gravis
gramicidins target gram -? gram +?
gram +
what common topical ointment contains gramicidin?
neosporin
T/F gramicidins are only used topically
True
what class of antibiotics is Daptomycin?
gramicidin
T/F Quinupristin/dalfopristin is given orally
False
what drug class is Quinupristin/dalfopristin?
streptogramins
