Fluoroquinolones

Question 1

mechanism of action?

Answer 1

disrupt DNA replication and function

Question 2

what two DNA enzymes do they target?

Answer 2

DNA topoisomerase II and DNA topoisomerase IV

Question 3

whats the name of the first quinolone?

Answer 3

nalidixic acid

Question 4

whats the name of the first fluoroquinolone?

Answer 4

norfloxacin

Question 5

norfloxican is used for gram +? gram -?

Answer 5

both

Question 6

norfloxacin is ___ more potent than nalidixic acid and broader

Answer 6

100x

Question 7

ciprofloxacin is ____ potent than norfloxacin and ____ absorbed

Answer 7

more, better

Question 8

ciprofloxacin is the most potent against?

Answer 8

pseudomonas

Question 9

levofloxacin is active against?

Answer 9

mycobacteria

Question 10

levofloxacin is used for?

Answer 10

MDR-TB

Question 11

Sparfloxacin and gatifloxacin were considered what drug class?

Answer 11

third generation fluoroquinolones

Question 12

third generation fluoroquinolones are more potent than previous generations against?

Answer 12

pneumococcus

Question 13

fourth generation fluoroquinolones are the most potent quinolone against?

Answer 13

pneumococcus

Question 14

what drug class is moxifloxacin?

Answer 14

4th gen fluoroquinolone

Question 15

moxifloxacin is very effective to treat?

Answer 15

tuberculosis

Question 16

what is gemifloxacin used for?

Answer 16

community acquired pneumonia and chronic bronchitis