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Infectious Diseases > Lec 3/4 > Flashcards

Lec 3/4 Flashcards

1
Q

Define mycoses

A

Disease caused by fungal infection

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2
Q

What does flucytosine do?

A

Inhibit nucleic acid synthesis of fungi

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3
Q

What do sordarins and azasordarins do?

A

Inhibit protein synthesis of fungi

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4
Q

What does griseofulvin do?

A

Disrupts microtubules and inhibits mitosis in fungi

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5
Q

What does echinocandin do?

A

Inhibits glucan synthesis to disrupt cell wall of fungi

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6
Q

What do nikkomycin and polyoxin do?

A

Inhibit chitin synthesis causing disruption of cell wall in fungi

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7
Q

What do azoles/allyamines do?

A

Inhibit ergosterol synthesis to disrupt cell membrane of fungi

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8
Q

List all of the imidazoles (COMET-K)

A 
Clotrimazole
Oxiconazole
Miconazole
Econazole
Tioconazole
Ketoconazole
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9
Q

List all of the triazoles (FIT VIP)

A 
Fluconazole
Itraconazole
Terconazole
Voriconazole
Isavuconazole
Posaconazole
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10
Q

What do azole antifungals inhibit?

A

Lanosterol demethylase which converts lanosterol into ergosterol

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11
Q

List all of the polyenes (NAN)

A

Natamycin
Amphotericin B
Nystatin

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12
Q

Name all of the echinocandins (MAC)

A

Micafungin
Anidulafungin
Caspofungin

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13
Q

List all of the allyamines (ANT)

A

Amorolfin
Naftifine
Terbinafine

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14
Q

What does histoplasmosis do?

Which drugs treat it?

A

Causes pulmonary infection that can spread to systemic system
Itraconazole and amphotericin B

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15
Q

What is dermatophytoses?

A

Infection of skin, hair, or nails

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Infectious Diseases (20 decks)

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