Tablet Disintegration And Dissolution

Question 1

How does wicking work?

Answer 1

These disintegrants are long fibrous materials which pull water in loosening inter-particle bonding. Disintegrant particles overlap passing water from one another

Question 2

How’s does deformation and repulsion occur?

Answer 2

Deformation- particles swell to pre impression size and break up matrix

Repulsion- water drawn into pores and particle repel due to electrical forces

Question 3

What is swelling?

Answer 3

Disintegrant particles in tablet absorb water and swell, this causes stress which spreads through matrix and break it from within

Question 4

What mechanism of disintegration does starch and microcrystalline cellulose use?

Answer 4

Starch - deformation and swelling

M. Cellulose- wicking

Question 5

What are the 3 super disintegrant and what is their mechanism of disintegration?

Answer 5

Sodium starch glycollate- extensive swelling

Croscarmellose type A - fast wicking action and fibre swelling

Crosspovidone- wicking