Evaluation Of Tablets Flashcards
1
Q
How is uniformity of content measured?
A
Using 10 doses it has to be between 85-115 percent of the average content using an assay
2
Q
How is disintegration measured?
A
Put tablets in water bath machine moves up and down
Uncoated tablets 15mins
Sugar/ film coating 30mins/60 mins
Enteric - immersion medium 0.1MHCl if disintegrate fails, immersion in phosphate buffer pH6.8 for 60mins
Effervescent- 5mins 15-25 degrees water
3
Q
How is resistance to abrasion measured?
A
Measure weight loss on subjecting tablets to a standard degree of agitation for standard time
0.8-1% weight loss allowed
4
Q
Define the process of uniformity of weight
A
Weigh 20 tablets determine average mass and no more than 2 can deviate from average mass by more than 1%
