Metabolism 2 Flashcards
1
Q
What is the equation of rate of elimination?
A
CL x C
2
Q
When does elimination occur?
A
if drug is a substrate to one or another elimination mechanisms within the cell
3
Q
What is the rate limiting step when Eh>0.7?
A
elimination will be by perfusion
4
Q
When Eh>0.7 is drug oral bioavailability high?
A
low & variable
5
Q
What is cirrhosis and which metabolism phase is affected?
A
parts of liver replaced by fibrous tissue and functional hepatocytes reduced
phase 1 oxidative metabolism affected
6
Q
What are the two theories which explain poor metabolism in cirrhosis?
A
sick cell - blood flow through liver normal but cells are deficient in drug metabolising enzyme
intact hepatocyte - cells normal but blood flow not
