T2DM drugs Flashcards
1
Q
MofA of metformin?
A
- inhibits hepatic gluconeogenesis
- increases glycolysis
- increases peripheral glucose uptake
Overall decreases glucose
2
Q
what is gluconeogenesis?
A
-generation of glucose from non carbohydrate substrates
3
Q
SE of metformin?
A
- lactic acidosis (especially in renal insufficiency)
- B12 deficiency
- GI upset
4
Q
MofA of sulfonylureas?
A
-increase release of insulin by depolarising K+ channels
5
Q
SE of sulfonylureas?
A
-hypoglycaemia
Do not prescribe to drivers!!
6
Q
examples of sulfonylureas?
A
- glimepirIDE
- glipizIDE
- glyburIDE
‘if I were you IDE take your sulfonylurea’
7
Q
MofA of DPP-4 inhibitors?
A
-inhibit DPP 4, potentiates GLP 1
8
Q
SE of DPP-4 inhibitors?
A
-recurrent UTIs
9
Q
examples of DPP-4 inhibitors?
A
- linagliptin
- saxagliptin
- sitagliptin
