drug notes: SGLT2i Flashcards
1
Q
what is an example of SGLT2i?
A
Dapagliflozin
Canagliflozin
Empagliflozin
2
Q
where is SGLT2 found?
A
in the kidney
3
Q
where is SGLT1 found?
A
in the gut
4
Q
what is the problem with phlorizin?
A
- very poorly absorbed orally
- non specific so inhibits SGLT1 as well resulting in osmotic diarrhoea
5
Q
what do SGLT2 inhibiotors do?
A
-they inhibit SGLT2 (sodium glucose transport proteins) in the kidneys, decreasing the amount of sugar uptake by one quarter and meaning that one quarter is just peed out
6
Q
what are some direct effects of SGLT2i?
A
- causes renal protection
- weight loss
- diuresis
- improved myocardial energetics
7
Q
what are some side effects of SGLT2i?
A
- thrush!! (you’re making them pee out sugar)
- fournier gangrene
- hypovolemia and hypotension
- diabetic ketoacidosis
8
Q
effect of SGLT2i on CV risk?
A
have a CV benefit
9
Q
effect of SGLT2i on renal?
A
it benefits renal system
10
Q
when would you take a SGLT2i ?
A
- high CVD, CKD or heart failure and second line to metformin
- NOT high CVD, CKD or heart failure but patient need another drug after metformin (second line to metformin) and are worried about hypoglycaemia
- NOT high CVD, CKD or heart failure but patient need another drug after metformin (second line to metformin) and need to lose weight
