T-cell Activation, CMI, Antigen Processing And Presentation Flashcards
1
Q
T-lymphocyte function
A
- destroy intracellular pathogens (antigen fragments) presented by MHC molecules
2
Q
TCR
A
- T cell antigen receptor
- 2 chain structure
- binding site for antigenic peptides
- most T cells have alpha/beta chains on TCR
- little t cells hace gamma/delta chains on TCR
- Both types of chains on TCR have CD3 and Zeta chain
3
Q
Cell mediated immunity does not involve_____
A
Antibodies
4
Q
Cell mediated immunity is
A
- activation of phagocytes, antigen specific cytotoxic t lymphocytes, helper t lymphocytes
- release cytokines
All in response to antigen
5
Q
Antigen presenting cells
A
- dendritic
- macrophages
- b cell
6
Q
Macrophages can also
A
- present antigens to t cells and initiate inflammation via cytokines such as IL-1, IL-6, nitric oxide, tumor necrosis factor alpha
7
Q
Function of alveolar macrophages
A
- remove small particles, dead cells, bacteria
- initiate and control immunity to resp. pathogens
8
Q
Function of kupffer cells
A
- hepatic tissue remodeling
- initiate immune response
9
Q
Function of microglia
A
- remove dead or old neurons
- control immunity of brain
10
Q
Splenic macrophage function
A
- eliminate old or dysfunctional RBCs
11
Q
TLRs
A
- toll like receptors
- bind to different pathogen components
- help macrophages recognize bacteria
12
Q
Helper T celld
A
- Recognize antigens on cells w/ MHC II
- CD4+
13
Q
Cytotoxic T cells
A
- recognize antigens synthesized inside cell w/ MHC I
- CD8+
14
Q
Steps in macrophage killing bacterial cells
A
- phagocytizes antigen
- processes antigens
- presents antigens to t cell
- t cell differentiation occurs
15
Q
Steps in cytotoxic t cells killing foreign antigens
A
- recognize antigens presented by MHC I
- perforin makes hole in infected cell membrane and enzymes enter
- infected cell destroyed
