Innate And Acquired Immunity Flashcards
1
Q
PAMPs
A
- pathogen associated molecular patterns
- glycoproteins and glycolipids on pathogen surfaces
2
Q
Immune responses
A
- Phagocytosis
- cytokines (secretion activate other defensive cells and attract them to site of invasion)
- antigens
- complement system
3
Q
Steps in phagocytosis
A
- Activation
- Chemotaxis
- Attachment
- Ingestion
- Digestion
- Exocytosis
4
Q
Classical pathway
A
- dependent on C1 complex
- antigen-antibody complex
5
Q
Alternative pathway
A
- C3 hydrolysis dependent
- activating surfaces
6
Q
Lectin pathway
A
- dependent on pathogen surfaces
- MASP-2 cleaves C2a
- C2 and C4
7
Q
MAC
A
- C5b, C6, C7, C8, C9
- Bind to pathogen membrane and cause cell to swell & burst
8
Q
Complement system
A
- proteins prod. In liver that circulate in blood
- eliminate pathogens by attracting leukocytes to site of invasion, tagging pathogens to help phagocytic cells ID and engulf them, killing pathogens by perforating membrane
9
Q
Other functions of complement proteins
A
- release histamine from mast cells
- removal of antigen-antibody complexes
10
Q
Stages of phagocytosis (picture not words)
A
- lysis
- opsonization
- activation of inflammatory response
- clearance of immune complexes
11
Q
PRRs
A
- pattern recognition receptors
- on phagocytic cells and recognize PAMPs
- sends signal to nucleus, activates phagocytosis genes, cellular prolif., production and secretion of antiviral interferons, proinflammatory cytokines, enhanced cell killing
12
Q
Deficiency in C3 & Factor B
A
Severe bacterial infection
13
Q
Deficiency in C3b-INA, C6, & C8
A
Severe neisseria meningitidis infection
14
Q
Deficiency in early Components (C1, C2, C4)
A
- Systemic lupus erythematous
- glomerulonephritis
- polymyostitis
15
Q
Deficiency in C1-inhibitor
A
- Hereditary angioma
