Systemic therapies Flashcards
1
Q
Cytotoxic chemo affects
A
all fast proliferating cells means its non-specific
2
Q
what agent is cyclophosphamide
A
alkylating
3
Q
what is cyclophosphamide used for
A
advanced breast cancer
-prior to rt or in combination with other drugs
4
Q
how does cyclophosphamide work
A
binds to DNA to stop it unwinding therefor stopping DNA replication
5
Q
what is Paclitaxel
A
a mitotic inhibitor
6
Q
what is paclitaxel used for
A
advanced breast cancer
- prior to rt
- after cyclophosphamide
7
Q
how does paclitaxel work
A
by disrupting the ability of the spindle apparatus to separate the chromatids during mitosis
8
Q
what stage does of mitosis does paclitaxel stop
A
occurs between metaphase and anaphase
9
Q
5 categories of cytotoxic chemo drugs
A
Interferes with DNA function • Antimetabolites • Alkylating agents • Topoisomerase inhibitors • Anti-tumour antibiotics Interferes with cell division • Mitotic inhibitors
