Pharmacokinetics

Question 1

Pharmacokinetics definition

Answer 1

what the body does to the drug

Question 2

Pharmacodynamics definition

Answer 2

what the drug does to the body

Question 3

ADME

Answer 3

Absorption
Distribution
Metabolism
Excretion

Question 4

Absorption/Administration

Answer 4

Oral, intravenous, subcutaneous, intramuscular and other routes like patches and inhalers

Question 5

bioavailability definition

Answer 5

the fraction of administered dose that reaches systemic circulation

Question 6

First - pass effect

Answer 6

Oral drugs have less bioavailability as it has to go through the GI tract and is filtered through the liver before getting into the systemic blood stream

Question 7

Distribution meaning

Answer 7

drugs in the systemic circuit need to move from intravascular space to extravascular space to reach the target

Question 8

Metabloism

Answer 8

Can be metabolised to be inactive or more active, largly via hepatic metabolism (liver)

Question 9

Excretion

Answer 9

Urine, fecec, sweat, breast milk, mainly through kidneys