QUANTEC DOSES

Question 1

Oesophagus

Answer 1

mean dose of less than 34Gy creates a 5-20% chance of a RTOG Grade 3+ oesophagitis, …Sever fibrosis…. dilation

Question 2

Heart

Answer 2

Considering the whole heart the volume receiving 25Gy should be less than 10% which creates a less than 1% chance of long term cardiac morality, months to years post treatment….. Heart transplant

Question 3

Lungs

Answer 3

state for the combined lungs the volume receiving 20 Gy has to be less than 30% to give a less than 20% chance of symptomatic pneumonitis……With a corticosteroid - prednisone

Question 4

Spinal Cord

Answer 4

maximum dose of 50Gy (partial organ) creates a less than 0.2% chance of the endpoint reaction with 3D-CRT, years post….Endpoint is radiation induced myelitis necrosis leading to paralysis… no treatment

Question 5

Stomach

Answer 5

45Gy to the whole organ for a less than 7% chance of ulceration, mucosal erosion and perforation months to years post treatment…..Pain medication for ulceration, surgery for perforation

Question 6

Kidney

Answer 6

for bilateral kidneys the volume receiving 28Gy should be less than 20% this creates a less than 5% chance of clinical dysfunction months to years post treatment….dialysis

Question 7

Small bowel

Answer 7

the volume receiving 45Gy should be less than 195cc for a less than 10% chance of RTOG grade 3 toxicity… RTOG Grade 3+ is obstruction/perforation or bleeding… surgery

Question 8

Bladder

Answer 8

maximum radiation dose of less than 65Gray to the whole organ creates a less than 6% of the Grade 3 late RTOG endpoint, months to years post….RTOG Grade 3 is severe frequency and dysuria, severe telangiectasia, frequent hematuria, reduction in bladder capacity

Question 9

Rectum

Answer 9

V50<50%, V60<35%, V65<25% doses for the rectum 3D-CRT for a less than 10% chance of a RTOG grade 2/3 late rectal toxicity months to years post treatment…RTOG ⅔ is moderate diarrhea, colic, bowel movement >5 times a day. Excessive mucus or intermediate bleeding…. Surgery

Question 10

penile bulb

Answer 10

50Gy to 90% of the gland creates a less than 35% chance of severe erectile dysfunction months to years post treatment

Question 11

larynx

Answer 11

A dose of less than 66 Gray within the organs
Causes a less than 20% chance of vocal dysfunction months post treatment. Endpoint occurs after decades

Ongoing speech therapy

Question 12

parotid

Answer 12

Bilateral whole parotid glands: a mean dose of less than 25 Gray for the combined parotids..Creates a less than 20% chance of long-term salivary function of less than 25%

Unilateral whole parotid gland: a mean dose of less than or equal to 20 Gray for a single parotid…..Creates a less than 20% chance of long long-term salivary function in the affected parotid of less than 25%

Question 13

brain

Answer 13

Maximum radiation dose of less than 60 Gray within the whole brain
creates a less than 3% chance of symptomatic necrosis months to years post treatment …
No treatment

Question 14

brain stem

Answer 14

Maximum radiation dose of less than 54 Gray within the organ
creates a less than 5% chance of the endpoint reaction occurring months to years post treatment

Neuropathy or necrosis
No treatment

Question 15

optic nerve

Answer 15

Maximum radiation dose of less than 55 Gray within the whole organ
creates a less than 3% chance of the endpoint reaction months to years post treatment

Optic neuropathy leading to blindness in associated eye
No treatment

Question 16

optic chiasm

Answer 16

Maximum dose of less than 55 Gray within the whole organ
Creates a less than 3% chance month to years post treatment of the endpoint reaction
Optic neuropathy leading to blindness in both eyes
No treatment