Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

NAPLEX 2022 > SYSTEMIC STEROIDS/AUTOIMMUNE CONDITIONS > Flashcards

SYSTEMIC STEROIDS/AUTOIMMUNE CONDITIONS Flashcards

1
Q

FLUDROCORTISONE MIMICS

A

ALDOSTERONE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

MINERALOCORTICOID ACTIVITY

A

BALANCE OF WATER AND ELECTROLYTES
STABILIZES BLOOD PRESSURE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

GLUCOCORTICOID ACTIVITY

A

ANTI-INFLAMMATORY

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

CUSHINGS SYNDROME

A

ADRENAL GLAND PRODUCES TOO MUCH CORTISOL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

ADDISONS DISEASE

A

ADRENAL GLAND IS NOT MAKING ENOUGH CORTISOL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

LONG TERM EFFECTS OF STEROIDS

A

PSYCHIATRIC CHANGES, HYPOTHYROIDISM
GLAUCOMA, CATARACTS
ACNE
FAT DEPOSITS IN FACE, ABDOMEN, UPPER BACK
GI BLEEDING/ULCERS
STRETCH MARKS AND EASY BRUISING
MUSCLE WASTING
DIABETES
POOR BONE HEALTH
HIRSUTISM
IRREGULAR PERIODS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

WAYS TO REDUCE SYSTEMIC STEROID RISKS

A

ALTERNATE DAY DOSING
USE LOCAL STEROIDS
FOR GUT, USE STEROID WITH LOW SYSTEMIC ABSORPTION
USE LOWEST POSSIBLE DOSE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

STEROIDS LEAST POTENT TO MOST
EQUIVALENT DOSES

A

CUTE HOT PHARMACISTS & OHYSICIANS MARRY TOGETHER & DELIVER BABIES
CORTISONE = 25 MG
HYDROCORTISONE = 20 MG
PREDNISONE = 5 MG
PREDNISOLONE = 5 MG
METHYLPREDNISOLONE = 4 MG
TRIAMCINOLONE = 4 MG
DEXAMETHASONE = 0.75 MG
BETAMETHASONE = 0.6 MG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

RATIO OF METHYLPREDISOLONE TO PREDNISONE

A

4 MG : 5 MG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

WHAT STEROID DOSE MAKES ONE IMMUNOSUPPRESSED

A

≥ 2 MG/KG/DAY OR
≥ 20 MG/DAY OF PREDNISONE FOR ≥ 2 WEEKS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

WHAT NON SPECIFIC LAB VALUES CAN BE USED TO DETECT INFLAMMATION

A

ERYTHROCYTE SEDIMENTATION RATE (ESR)
C REACTIVE PROTEIN (CRP)
RHEUMATOID FACTOR (RF)
ANTI-NUCLEAR ANTIBODY (ANA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

MEDROL THERAPY PACK DOSING

A

21 COUNT OF 4 MG TABLETS

2/1/1/2
1/1/1/2
1/1/1/1
1/1/1
1/1
1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

USE OF STRONG IMMUNOSUPPRESSANTS CAN INCREASE THE RISK OF

A

REACTIVATION OF TB, HEP B AND HEP C
VIRUSES
LYMPHOMAS OR SKIN CANCERS
INFECTIONS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

CLINICAL PRESENTATION OF RHEUMATOID ARTHRITIS

A

BILATERAL SYMMETRICAL
MORNING STIFFNESS
JOINT SWELLING
PAIN
BONE DEFORMITY

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

WHAT LAB TESTS CAN BE USED TO IDENTIFY RHEUMATOID ARTHRITIS

A

ACPA
RF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

REGARDLESS OF SEVERITY, SYMPTOMATIC RA SHOULD BE STARTED ON

A

DMARD TO SLOW DISEASE PROCESS AND PREVENT FURTHER JOINT DAMAGE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

WHAT IS THE PREFERRED INITAL THERAPY FOR RA

A

METHOTREXATE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

STEROID USE IN RA

A

LOWEST DOSE POSSIBLE FOR THE SHORTEST DURATION

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

MTX DOSING FOR RA

A

7.5 - 20 MG ONCE WEEKLY

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

TRADITIONAL NON-BIOLOGIC DMARDS IN RA

A

METHOTREXATE
HYDROQXYCHLOROQUINE
SULFASALAZINE
LEFLUNOMIDE
JAK INHIBITORS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

HYDROXYCHLOROQUINE WARNING

A

IRREVERSIBLE RETINOPATHY
CARDIOMYOPATHY, QT PROLONGATION

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

SULFASALAZINE CONTRAINDICATION

A

SULFA OR SALICYLATE ALLERGY

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

LEFLUNOMIDE BOXED WARNING

A

DO NOT USE IN PREGNANCY
HEPATOTOXICITY

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

LEFLUNOMIDE ACCELERATED DRUG ELIMINATION OPTIONS

A

PURPOSE: TO REMOVE ACTIVE METABOLITE
CHOLESTYRAMINE
ACTIVATED CHARCOAL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

LEFLUNOMIDE AND PREGNANCY

A

MUST HAVE NEGATIVE PREGNANCY TEST
USE 2 FORMS OF BIRTH CONTROL DURING TREATMENT
MUST WAIT 2 YEARS AFTER DC OR USE ACCELERATED DRUG ELIMINATION TO BE PREGNANT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

JAK INHIBITOR AGENTS

A

TOFACTINIB
BARICITINIB
UPADACITINIB

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

JAK INHIBITORS BOXED WARNING

A

SERIOUS INFECTIONS
MALIGNANCY
THROMBOSIS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

CAN JAK INHIBITORS BE USED WITH BIOLOGIC DMARDS

A

NO

29
Q

ANTI-TNF BIOLOGIC DMARDS

A

ETANERCEPT (ENBREL)
ADALIMUMAB (HUMIRA)
INFLIXIMAB (REMICADE)
CERTOLIZUMAB (CIMZIA)
GOLIMUMAB (SIMPONI)

30
Q

WHICH ANTI-TNF BIOLOGICS NEED TO BE USED WITH MTX

A

REMICADE
SIMPONI

31
Q

ENGREL DOSING FREQUENCY

A

WEEKLY

32
Q

HUMIRA DOSING FREQUENCY

A

EVERY OTHER WEEK

33
Q

REMICADE ADMINISTRATION

A

IV

34
Q

CIMZIA DOSING FREQUENCY

A

EVERY OTHER WEEK

35
Q

SIMPONI DOSING FREQUENCY

A

MONTHLY

36
Q

REMICADE WARNINGS

A

INFUSION REACTIONS
DELAYED HYPERSENSITIVITY

37
Q

ANTI-TNF BOXED WARNINGS

A

SERIOUS INFECTIONS, SCREEN FOR LATENT TB
MALIGNANCIES

38
Q

ANTI-TNF WARNINGS

A

DEMYELINATING DISEASE
HEP B REACTIVATION
HF
HEPATOTOXICITY
LUPUS-LIKE REACTION

39
Q

RITUXIMAB (RITUXAN) MOA

A

ANTI-CD 20 B CELLS

40
Q

RITUXAN ADMINISTRATION

A

IV
WITH MTX
PREMEDICATION WITH STEROID, APAP, ANTIHISTAMINE

41
Q

CLINICAL PRESENTATION OF SLE

A

FATIGUE, DEPRESSION
ANOREXIA, WEIGHT LOSS,
MUSCLE PAIN
BUTTERFLY RASH
PHOTOSENSITIVITY
JOINT PAIN, STIFFNESS

42
Q

KEY DRUGS THAT CAN INDUCE LUPUS ERYTHEMATOSUS

A

MY PRETTY MALAR MARKING PROBABLY HAS A TRANSIENT QUALITY
METHIMAZOLE
PTU
METHYLDOPA
MINOCYCLINE
PROCAINAMIDE
HYDRALAZINE
ANTI-TNF
TERBINAFINE
ISONIAZID
QUINIDINE

43
Q

LAB FINDINGS IN SLE

A

POSITIV ANA
ANTI-SSDNA
AND-DSDNA

44
Q

SLE DRUG TREATMENT

A

HYDROXYCHLOROQUINE
CYCLOPHOSPHAMIDE
AZATHIOPRINE
MYCOPHENOLATE
CYCLOSPORINE

45
Q

BELIMUMAB (BENLYSTA) USE

A

SLE BY REDUCE ACIVITY OF B-CELL MEDIATEDD IMMUNITY AND AUTOIMMUNE RESPONSE

46
Q

BELIMUMAB (BENLYSTA) WARNINGS

A

SERIOUS INFECTIONS
DO NOT GIVE WITH OTHER BIOLOGIC DMARDS OR LIVE VACCINES

47
Q

CALCINEURIN INHIBITOR WARNINGS

A

INFECTIONS, MALIGNANCIES
NEPHROTOXICITY,
HTN

48
Q

MULTIPLE SCLEROSIS PRESENTATION

A

FATIGUE
NUMBNESS
BLURRED VISION
DETERIORATION OF COGNITIVE FUNCTION
MUSCLE SPASMS
PAIN
INCONTINENCE
GAIT INSTABILITY

49
Q

DMARD FOR MS

A

INTERFERON BETA FORMULATIONS
GLATIRAMER ACETATE

50
Q

COPAXONE MOA

A

GLATIRAMER ACETATE
IMMUNE MODULATOR

51
Q

COPAXONE DOSING FREQUENCY

A

SC DAILY OR
SC 3 TIMES/WEEK

52
Q

COPAXONE WARNINGS

A

CHEST PAIN

53
Q

COPAXONE SIDE EFFECTS

A

INJECTION SITE REACTION
FLUSHING
DIAPHRESIS
DYSPNEA

54
Q

WHICH AGENT IS PREFERRED FOR MS IN PREGNANCY

A

COPAXONE

55
Q

INTERFERON BETA PRODUCTS

A

AVONEX, REBIF
PLEGRIDY
BETASERON, EXTAVIA

56
Q

AVONEX DOSING VS REBIF DOSING

A

IM WEEKLY VS
SC 3X/WEEK

57
Q

INTERFERON BETA PRODUCT WARNINGS

A

PSYCHIATRIC DISORDERS
INJECTION SITE NECROSIS
↑LFT
THYROID DYSFUNCTION

58
Q

SPHINGOSINE 1-PHOPHATE RECEPTOR MODULATORS CONTRAINDICATION

A

ARRYTHMIAS AND OTHER CV CONDITIONS
OZANIMOD: USE WITH MAOI
SIPONIMOD: CYP2C93/3

59
Q

SPHINGOSINE 1-PHOPHATE RECEPTOR MODULATORS WARNINGS

A

SLOW HR
SHOULD MONITOR FOR 6 HOURS AFTER FIRST DOSE
ECG REQUIRED AT BASELINE
MACULAR EDEMA (NEED EYE EXAMS)

60
Q

NATALIZUMAB (TYSABRI) MOA

A

MONOCLONAL ANTIBODY BINDS TO INTEGRINS ON LEUKOCYTES

61
Q

TYSARBI BOXED WARNING

A

PML
ONLY AVAILABLE THROUGH REMS PROGRAM

62
Q

WHICH DRUGS CAN WORSEN RAYNAUD’S

A

BETA BLOCKERS
BLEOMYCIN, CISPLATIN
SYMPATHOMIMETICS, AMPHETAMINES, SUDOFED, ILLICIT DRUGS

63
Q

RAYNAUD’S PREVENTION AND TREATMENT

A

CCB NIFEDIPINE

64
Q

MYASTHENIA GRAVIS SYMPTOMS

A

CHANGES TO EYES/VISION
DROOPING EYELID (PTOSIS)

65
Q

WHAT DRUGS CA WORSEN MYASTHENIA GRAVIS

A

ABX: AMINOGLYCOSIDE AND QUINOLONES
MG SALTS
ANTIARRHYTHMICS
BB AND CCB
ANTIPSYCHOTICS
MUSCLE RELAXANTS
LOCAL ANESTHETICS

66
Q

MYASTHENIA GRAVIS TREATMENT

A

CHOLINESTERASE INHIBITORS - BLOCK THE BREAKDOWN OF ACh, IMPROVING TRANSMISSION AND INCREASE MUSCLE STRENGTH

67
Q

SJOGRENS CHARACTERISTICS

A

DRY EYES AND DRY MOUTH

68
Q

SJOGRENS TREATMENT

A

CYCLSPORINE EYE DROPS (RESTASIS)

NAPLEX 2022 (37 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions