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NAPLEX 2022 > Infectious Diseases - PART 3 > Flashcards

Infectious Diseases - PART 3 Flashcards

1
Q

DAPTOMYCIN COVERAGE

A

MOST GP BACTERIA (MRSA, VRE)
NO GN ACTIVITY

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2
Q

WHEN SHOULD YOU NOT USE DAPTOMYCIN

A

PNEUMONIA
INACTIVATED BY LUNG SURFACTANT

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3
Q

DAPTOMYCIN INDICATIONS

A

SSTI
STAPH BLOODSTREAM INFECTIONS (MRSA)
ENDOCARDITIS

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4
Q

DAPTOMYCIN WARNING

A

MYOPATHY AND RHABDOMYOLYSIS
FALSE ↑ PT/INR

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5
Q

LINEZOLID COVERAGE

A

MRSA AND VRE

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6
Q

LINEZOLID RENAL DOSE ADJUSTMENT?

A

NOT NEEDED

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7
Q

LINEZOLID BIOAVAILABILITY

A

IV:PO 1:1

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8
Q

LINEZOLID CONTRAINDICATION

A

DO NOT USE WITHIN 2 WEEKS OF MAOI

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9
Q

LINEZOLID WARNING

A

DURATION RELATED MYELOSUPPRESSION (THROMBOCYTOPENIA)
OPTIC NEUROPATHY
SEROTONIN SYNDROME
HYPOGLYCEMIA

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10
Q

LINEZOLID SUSPENSION. ADMINISTRATION

A

DO NOT SHAKE

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11
Q

QUINUPRISTIN/DALFOPRISTIN SIDE EFFECTS

A

ARTHRALGIAS/MYALGIAS
INFUSION REACTIONS
HYPERBILIRUBINEMIA

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12
Q

QUINUPRISTIN/DALFOPRISTIN ADMINISTRATION

A

DILUTE WITH D5W ONLY
ADMINISTER VIA CENTRAL LINE ONLY

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13
Q

TIGECYCLINE COVERAGE

A

BROAD SPECTRUM GP (MRSA, VRE)
GN BACTERIA, ANAEROBES, ATYPICAL

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14
Q

QUINUPRISTIN/DALFOPRISTIN COVERAGE

A

MRSA
VRE (BUT NOT E.FAECALIS)

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15
Q

QUINUPRISTIN/DALFOPRISTIN IS NOT WELL TOLERATED, SO ONLY USED FOR THIS INFECTION

A

VRE E.FAECIUM INFECTIONS

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16
Q

TIGECYCLINE DOES NOT HAVE COVERAGE TO

A

3 P’S
PSEUDOMONAS
PROTEUS
PROVIDENCIA

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17
Q

TIGECYCLINE HAS LIMITED USES
WHAT ARE THE INDICATIONS?

A

COMPLICATED SSTI
INTRA-AB INFECTION
CA-PNEUMONIA

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18
Q

TIGECYCLINE BOXED WARNING

A

↑ RISK OF DEATH
ONLY USE WHEN NECESSARY

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19
Q

DO NOT USE TIGECYCLINE FOR THSES INFECTIONS

A

BLOODSTREAM INFECTIONS
DOES NOT ACHIEVE ADEQUATE CONCENTRATIONS

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20
Q

WHAT COLOR SHOULD TIGECYCLINE BE WHEN RECONSTITUTED

A

YELLOW-ORANGE COLOR

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21
Q

POLYMIXINS ARE PRIMARILY USED FOR

A

MDR GRAM NEGATIVE PATHOGENS

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22
Q

POLYMIXIN WARNING

A

NEPHROTOXICITY
NEUROTOXICITY THAT CAN LEAD TO RESPIRATORY PARALYSIS

23
Q

CHLORAMPHENICOL BOXED WARNING

A

SERIOUS AND FATAL BLOOD DYSCARIAS

24
Q

CHLORAMPHENICOL WARNING

A

GRAY SYNDROME WITH HIGH SERUM LEVELS: CIRUCULATORY COLLAPSE, CYANOSIS, ACIDOSIS,COMA, DEATH

25
Q

CLINDAMYCIN COVERAGE

A

MOST GP BACTERIA (SOME CA-MRSA)
ANAEROBES
NO GN COVERAGE

26
Q

CLINDAMYCIN RENAL DOSE ADJUSTMENT NEEDED?

A

NOT NEEDED

27
Q

CLINDAMYCIN BOXED WARNING

A

COLITIS (C.DIFF)

28
Q

WHAT TEST SHOULD BE PERFORMED PRIOR TO USING CLINDAMYCIN ON S.AUREUS?

A

INDUCTION TEST (D-TEST)
TEST IF BUG WILL INDUCE RESISTANCE

29
Q

CLINDAMYCIN COMMON USE

A

PURULENT AND NON-PURULENT SKIN INFECTIONS
DENTAL ABSCESSES (BETA LACTAM ALTERNATIVE)

30
Q

METRONIDAZOLE COVERAGE

A

ANAEROBES AND PROTOZOAL INFECTIONS

31
Q

METRONIDAZOLE IS EFFECTIVE IN THESE INFECTIONS

A

BACTERIAL VAGINOSIS
TRICHOMONIASIS
IN COMBO FOR INTRA-AB INFECTIONS

32
Q

METRONIDAZOLE BIOAVAILABILITY

A

IV:PO 1:1

33
Q

METRONIDAZOLE CONTRAINDICATIONS

A

PREGNANCY 1ST TRIMESTER
ALCOHOL OR PROPYLENE GLYCOL CONTAINING PRODUCTS DURING OR WITHIN 3 DAYS OF TREATMENT D/C

34
Q

FIDAXOMIXIN IS ONLY INDICATED FOR

A

C.DIFF
NOT EFFECTIVE FOR SYSTEMIC INFECTIONS

35
Q

RIFAXIMIN HAS 4 MAIN INDICATIONS

A

TRAVELER’S DIARRHEA
↓ RECURRENCE OF HEPATIC ENCEPHALOPATHY
IBS-D
C.DIFF (OFF-LABEL)

36
Q

RIFAXIMIN BIOAVAILABILITY

A

<1% ABSORPTION
NOT EFFECTIVE FOR SYSTEMIC INFECTIONS

37
Q

FOSFOMYCIN COVERAGE

A

E.COLI (INCLUDING ESBL)
F.FAECALIS (INCLUDING VRE)

38
Q

FOSFOMYCIN INDICATION AND DOSING

A

SINGLE DOSE REGIMEN FOR UNCOMPLICATED UTI

39
Q

FOSFOMYCIN PACKET GRANULES CONTAIN HOW MANY GRAMS

A

3 GRAMS PER PACKET

40
Q

NITROFURANTOIN USE

A

UTI (CYSTITIS ONLY)

41
Q

NITROFURANTOIN COVERAGE

A

E.COLI
KLEBSIELLA
ENTEROBACTER
S.AUREUS
ENTEROCOCCUS (VRE)

42
Q

WHAT IS THE DRUG OF CHOICE FOR UNCOMPLICATED UTI

A

NITROFURANTOIN

43
Q

MICROBID VS MICRODANTIN

A

MACROBID IS BID DOSING
MACRODANTIN IS QID DOSING

44
Q

MACROBID DOSING FOR UNCOMPLICATED UTI

A

100 MG BID X 5 DAYS

45
Q

NITROFURANTOIN CONTRAINDICATIONS

A

RENAL IMPAIRMENT < 60

46
Q

NITROFURANTOIN WARNING

A

HEMOLYTIC ANEMIA IN G6PD DEFICIENCY

47
Q

RIFAMPIN SIDE EFFECTS

A

↑ LFTS
HEMOLYTIC ANEMIA (POSITIVE COMMBS TEST)
FLU LIKE SX
ORANGE-RED DISCOLORATION OF SECRETIONS

48
Q

ISONIAZID: WHAT VITAMIN SHOULD BE TAKEN WITH THIS AGENT AND WHY?

A

PYRIDOXINE (VITAMIN B6)
TO ↓ RISK OF INH-ASSOCIATED PRIPPHERAL NEUROPATHY

49
Q

ISONIAZID BOXED WARNING

A

HEPATITIS

50
Q

ISONIAZID WARNING

A

PERIPHERAL NEUROPATHY (RECOMMENDED TO TAKE PYRIDOXINE AS SUPPLEMENTAL)

51
Q

ISONIAZID SIDE EFFECTS

A

↑ LFTS
DILE
HEMOLYTIC ANEMIA

52
Q

PYRAZINAMIDE WARNING

A

ACUTE GOUT CAUSED BY HYPERURICEMIA/GOUT

53
Q

ETHAMBUTOL WARNINGS

A

OPTIC NEURITIS
CONFUSION AND HALLUCINATIONS

54
Q

PHENAZOPYRIDINE

A

NAPLEX 2022 (37 decks)

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