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NAPLEX 2022 > ONCOLOGY OVERVIEW > Flashcards

ONCOLOGY OVERVIEW Flashcards

1
Q

WHICH HIGHLY TOXIC DRUGS HAVE DOSING CONSIDERATIONS?

A

BLEOMYCIN
DOXORUBICIN
CISPLATIN
VINCRISTINE

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2
Q

BLEOMYCIN MAXIMUM DOSE

A

LIFETIME CUMULATIVE DOSE OF 400 UNITS

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3
Q

DOXORUBICIN MAXIMUM DOSE

A

LIFETIME CUMULATIVE DOSE OF 450 - 550 MG/M2

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4
Q

CISPLATIN MAXIMUM DOSE

A

DOSES PER CYCLE NOT TO EXCEED 100 MG/M2

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5
Q

VINCRISTINE MAXIMUM DOSE

A

SINGLE DOSE CAPPED AT 2 MG

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6
Q

WHAT IS THE REASON FOR THE MAX DOSE CAP FOR BLEOMYCIN

A

PULMONARY TOXICITY

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7
Q

WHAT IS THE REASON FOR THE MAX DOSE CAP FOR DOXORUBICIN

A

CARDIOTOXICITY

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8
Q

WHAT IS THE REASON FOR THE MAX DOSE CAP FOR CISPLATIN

A

NEPHROTOXICITY

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9
Q

WHAT IS THE REASON FOR THE MAX DOSE CAP FOR VINCRISTINE

A

NEUROPATHY

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10
Q

MOST AGENTS WILL CAUSE MYELOSUPPRESSION. WHICH ONES DO NOT?

A

ASPARAGINASE
BLEOMYCIN
VINCRISTINE
MABS AND TKIS

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11
Q

COMMMON DRUGS TO CAUSE N&V

A

CISPLATIN
CYCLOPHOSPHAMIDE
IFOSFAMIDE

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12
Q

COMMMON DRUGS TO CAUSE MUCOSITIS

A

FLUOROURACIL
METHOTREXATE

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13
Q

COMMMON DRUGS TO CAUSE DIARRHEA

A

IRINOTECAN
CAPECITABINE
FLUOROURCIL
METHOTREXATE

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14
Q

COMMMON DRUGS TO CAUSE CONSTIPATION

A

VINCRISTINE

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15
Q

COMMMON DRUGS TO CAUSE XEROSTOMIA

A

NONE
USUALLY CAUSED BY RADIATION

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16
Q

COMMMON DRUGS TO CAUSE CARDIOMYOPATHY

A

ANTHRACYCLINES

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17
Q

COMMMON DRUGS TO CAUSE QT PROLONGATION

A

ARSENIC TRIOXIDE
TKIS

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18
Q

COMMMON DRUGS TO CAUSE PULMONARY FIBROSIS

A

BLEOMYCIN
BUSULFAN
CARMUSTINE
LOMUSTINE

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19
Q

COMMMON DRUGS TO CAUSE PENUMONITIS

A

IMMUNE THERAPY MABS

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20
Q

COMMMON DRUGS TO CAUSE HEPATOTOXICITY

A

ANTIANDROGENS (BICALUTAMIDE, FLUTAMIDE, NILATAMIDE)

21
Q

COMMMON DRUGS TO CAUSE NEPHROTOXICITY

A

CISPLATIN
METHOTREXATE

22
Q

COMMMON DRUGS TO CAUSE HEMMORRHAGIC CYSTITIS

A

IFOSFAMIDE (ALL DOSES)
CYCLOPHOSPHAMIDE (HIGH DOSES)

23
Q

COMMMON DRUGS TO CAUSE PERIPHERAL NEUROPATHY

A

VINCA ALKALOIDS
PLATINUMS
TAXANES

24
Q

COMMMON DRUGS TO CAUSE AUTONOMIC NEUROPATHY

A

VINCA ALKALOIDS

25
Q

COMMMON DRUGS TO CAUSE THROMBOEMBOLIC RISK (CLOTTING)

A

AROMATASE INHIBITORS
SERMS

26
Q

NITROSUREAS MAJOR TOXICITY

A

NEUROTOXICITY

27
Q

PLATINUM-BASED AGENTS MAJOR TOXICITY

A

NEPHROTOXIC
OTOTOXIC

28
Q

METHOTREXATE MAJOR TOXICITY

A

MUCOSITIS

29
Q

BLEOMYCIN, BUSULFAN, NITROSUREAS MAJOR TOXICITY

A

PULMONARY FIBROSIS

30
Q

DOXORUBICIN AND OTHER ANTHRACYCLINES MAJOR TOXICITY

A

CARDIOTOXIC

31
Q

IMMUNOTHERAPY MAJOR TOXICITY

A

WIDE SPREAD AUTOIMMUNE SYNDROMES

32
Q

IFOSFAMIDE AND CYCLOPHOSPHAMIDE MAJOR TOXICITY

A

HEMORRHAGIC CYSTITIS

33
Q

VINCA ALKALOIDS MAJOR TOXICITY

A

PERIPHERAL NEUROPATHY

34
Q

TAXANES MAJOR TOXICITY

A

PERIPHERAL NEUROPATHY

35
Q

MANAGEMENT FOR NEUTROPENIA

A

CSFs

36
Q

MANAGEMENT FOR ANEMIA

A

RBC TRANSFUSIONS
ESAs FOR PALLIATIVE CARE ONLY

37
Q

MANAGEMENT FOR N&V

A

NK1-RA
5HT3-RA
DEXAMETHASONE
IV/PO FLUID HYDRATION

38
Q

MANAGEMENT FOR MUCOSITIS

A

SYMPTOMATIC TREATMENT

39
Q

MANAGEMENT FOR DIARRHEA

A

IV/PO HYDRATION
ANTIMOTILITY AGENTS

40
Q

MANAGEMENT FOR FOR IRINOTECAN DIARRHEA

A

ATROPINE FOR EARLY ONSET DIARRHEA

41
Q

MANAGEMENT FOR CONSTIPATION

A

STIMULANT LAXATIVES
PEG 3350

42
Q

MANAGEMENT FOR XEROSTOMIA

A

ARTIFICIAL SALIVA SUBSTITUTES
PILOCARPINE

43
Q

CHEMO ADJUNCTIVE TO CISPLATIN AND WHY?

A

AMIFOSTINE (ETHYOL) AND HYDRATION
NEPHROTOXICITY PROPHYLAXIS

44
Q

CHEMO ADJUNCTIVE TO DOXORUBICIN AND WHY

A

DEXRAZOXANE (ZINECARD, TOTECT)
CARDIOMYOPATHY PROPHYLAXIS

45
Q

CHEMO ADJUNCTIVE TO FLUOROURACIL AND WHY

A

LEUCOVORIN OR LEVLEUCOVORIN (FUSILEV)
TO ENHANCE EFFICACY AS A COFACTOR

46
Q

CHEMO ADJUNCTIVE TO FLUOROURACIL AND CAPECITABINE AND WHY

A

URIDINE TRACETATE (VISTOGARD)
ANTIDOTE
USE WITHIN 96 HOURS FOR AN OVERDOSE OR TO TREAT SEVERED LIFE THREATENING OR EARLY ONSET TOXICITY

47
Q

CHEMO ADJUNCTIVE TO IFOSFAMIDE AND WHY

A

MESNA (MESNEX)
HEMORRHAGIC CYSTITIS PROPHYLAXIS

48
Q

CHEMO ADJUNCTIVE TO IRINOTECAN ADN WHY

A

ATROPINE FOR ACUTE DIARRHEA
LOPERAMIDE FOR DELAYED DIARRHEA

49
Q

CHEMO ADJUNCTIVE TO METHOTREXATE AND WHY

A

LEUCOVORIN OR LEVOLEUCOVORIN (FUSILEV) FOR MYELOSUPPRESSION AND MUCOSITIS PROPHYLAXIS
GLUCARPIDASE (VORAXAZE) IS AN ANTIDOTE FOR EXCESSIVE LEVELS

NAPLEX 2022 (37 decks)

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