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NAPLEX 2022 > ONCOLOGY OVERVIEW > Flashcards

ONCOLOGY OVERVIEW Flashcards

1
Q

WHICH HIGHLY TOXIC DRUGS HAVE DOSING CONSIDERATIONS?

A

BLEOMYCIN
DOXORUBICIN
CISPLATIN
VINCRISTINE

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2
Q

BLEOMYCIN MAXIMUM DOSE

A

LIFETIME CUMULATIVE DOSE OF 400 UNITS

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3
Q

DOXORUBICIN MAXIMUM DOSE

A

LIFETIME CUMULATIVE DOSE OF 450 - 550 MG/M2

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4
Q

CISPLATIN MAXIMUM DOSE

A

DOSES PER CYCLE NOT TO EXCEED 100 MG/M2

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5
Q

VINCRISTINE MAXIMUM DOSE

A

SINGLE DOSE CAPPED AT 2 MG

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6
Q

WHAT IS THE REASON FOR THE MAX DOSE CAP FOR BLEOMYCIN

A

PULMONARY TOXICITY

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7
Q

WHAT IS THE REASON FOR THE MAX DOSE CAP FOR DOXORUBICIN

A

CARDIOTOXICITY

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8
Q

WHAT IS THE REASON FOR THE MAX DOSE CAP FOR CISPLATIN

A

NEPHROTOXICITY

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9
Q

WHAT IS THE REASON FOR THE MAX DOSE CAP FOR VINCRISTINE

A

NEUROPATHY

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10
Q

MOST AGENTS WILL CAUSE MYELOSUPPRESSION. WHICH ONES DO NOT?

A

ASPARAGINASE
BLEOMYCIN
VINCRISTINE
MABS AND TKIS

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11
Q

COMMMON DRUGS TO CAUSE N&V

A

CISPLATIN
CYCLOPHOSPHAMIDE
IFOSFAMIDE

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12
Q

COMMMON DRUGS TO CAUSE MUCOSITIS

A

FLUOROURACIL
METHOTREXATE

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13
Q

COMMMON DRUGS TO CAUSE DIARRHEA

A

IRINOTECAN
CAPECITABINE
FLUOROURCIL
METHOTREXATE

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14
Q

COMMMON DRUGS TO CAUSE CONSTIPATION

A

VINCRISTINE

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15
Q

COMMMON DRUGS TO CAUSE XEROSTOMIA

A

NONE
USUALLY CAUSED BY RADIATION

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16
Q

COMMMON DRUGS TO CAUSE CARDIOMYOPATHY

A

ANTHRACYCLINES

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17
Q

COMMMON DRUGS TO CAUSE QT PROLONGATION

A

ARSENIC TRIOXIDE
TKIS

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18
Q

COMMMON DRUGS TO CAUSE PULMONARY FIBROSIS

A

BLEOMYCIN
BUSULFAN
CARMUSTINE
LOMUSTINE

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19
Q

COMMMON DRUGS TO CAUSE PENUMONITIS

A

IMMUNE THERAPY MABS

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20
Q

COMMMON DRUGS TO CAUSE HEPATOTOXICITY

A

ANTIANDROGENS (BICALUTAMIDE, FLUTAMIDE, NILATAMIDE)

21
Q

COMMMON DRUGS TO CAUSE NEPHROTOXICITY

A

CISPLATIN
METHOTREXATE

22
Q

COMMMON DRUGS TO CAUSE HEMMORRHAGIC CYSTITIS

A

IFOSFAMIDE (ALL DOSES)
CYCLOPHOSPHAMIDE (HIGH DOSES)

23
Q

COMMMON DRUGS TO CAUSE PERIPHERAL NEUROPATHY

A

VINCA ALKALOIDS
PLATINUMS
TAXANES

24
Q

COMMMON DRUGS TO CAUSE AUTONOMIC NEUROPATHY

A

VINCA ALKALOIDS

25
COMMMON DRUGS TO CAUSE THROMBOEMBOLIC RISK (CLOTTING)
AROMATASE INHIBITORS SERMS
26
NITROSUREAS MAJOR TOXICITY
NEUROTOXICITY
27
PLATINUM-BASED AGENTS MAJOR TOXICITY
NEPHROTOXIC OTOTOXIC
28
METHOTREXATE MAJOR TOXICITY
MUCOSITIS
29
BLEOMYCIN, BUSULFAN, NITROSUREAS MAJOR TOXICITY
PULMONARY FIBROSIS
30
DOXORUBICIN AND OTHER ANTHRACYCLINES MAJOR TOXICITY
CARDIOTOXIC
31
IMMUNOTHERAPY MAJOR TOXICITY
WIDE SPREAD AUTOIMMUNE SYNDROMES
32
IFOSFAMIDE AND CYCLOPHOSPHAMIDE MAJOR TOXICITY
HEMORRHAGIC CYSTITIS
33
VINCA ALKALOIDS MAJOR TOXICITY
PERIPHERAL NEUROPATHY
34
TAXANES MAJOR TOXICITY
PERIPHERAL NEUROPATHY
35
MANAGEMENT FOR NEUTROPENIA
CSFs
36
MANAGEMENT FOR ANEMIA
RBC TRANSFUSIONS ESAs FOR PALLIATIVE CARE ONLY
37
MANAGEMENT FOR N&V
NK1-RA 5HT3-RA DEXAMETHASONE IV/PO FLUID HYDRATION
38
MANAGEMENT FOR MUCOSITIS
SYMPTOMATIC TREATMENT
39
MANAGEMENT FOR DIARRHEA
IV/PO HYDRATION ANTIMOTILITY AGENTS
40
MANAGEMENT FOR FOR IRINOTECAN DIARRHEA
ATROPINE FOR EARLY ONSET DIARRHEA
41
MANAGEMENT FOR CONSTIPATION
STIMULANT LAXATIVES PEG 3350
42
MANAGEMENT FOR XEROSTOMIA
ARTIFICIAL SALIVA SUBSTITUTES PILOCARPINE
43
CHEMO ADJUNCTIVE TO CISPLATIN AND WHY?
AMIFOSTINE (ETHYOL) AND HYDRATION NEPHROTOXICITY PROPHYLAXIS
44
CHEMO ADJUNCTIVE TO DOXORUBICIN AND WHY
DEXRAZOXANE (ZINECARD, TOTECT) CARDIOMYOPATHY PROPHYLAXIS
45
CHEMO ADJUNCTIVE TO FLUOROURACIL AND WHY
LEUCOVORIN OR LEVLEUCOVORIN (FUSILEV) TO ENHANCE EFFICACY AS A COFACTOR
46
CHEMO ADJUNCTIVE TO FLUOROURACIL AND CAPECITABINE AND WHY
URIDINE TRACETATE (VISTOGARD) ANTIDOTE USE WITHIN 96 HOURS FOR AN OVERDOSE OR TO TREAT SEVERED LIFE THREATENING OR EARLY ONSET TOXICITY
47
CHEMO ADJUNCTIVE TO IFOSFAMIDE AND WHY
MESNA (MESNEX) HEMORRHAGIC CYSTITIS PROPHYLAXIS
48
CHEMO ADJUNCTIVE TO IRINOTECAN ADN WHY
ATROPINE FOR ACUTE DIARRHEA LOPERAMIDE FOR DELAYED DIARRHEA
49
CHEMO ADJUNCTIVE TO METHOTREXATE AND WHY
LEUCOVORIN OR LEVOLEUCOVORIN (FUSILEV) FOR MYELOSUPPRESSION AND MUCOSITIS PROPHYLAXIS GLUCARPIDASE (VORAXAZE) IS AN ANTIDOTE FOR EXCESSIVE LEVELS

NAPLEX 2022 (37 decks)

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