DRUG INTERACTIONS Flashcards
1
Q
WARFARIN INTERACTIONS
A
THE S ISOMER IS A SUBSTRATE OF CYP2C9
2
Q
WHICH STATINs HAS THE LOWEST POTENTIAL FOR DDI?
A
PRAVASTATIN AND ROSUVASTATIN ARE NOT METABOLIZED BY CYP3A4
3
Q
COMMON CYP INHIBITORS
A
G-PACMAN GRAPEFRUIT PROTEASE INHIBITORS AZOLE ANTIFUNGALS CYCLOSPORINE, COBICISTAT MACROLIDES AMIODARONE NON-DHP CCBS
4
Q
COMMON CYP INDUCERS
A
PS PORCS PHENYTOIN SMOKING PHENOBARBITAL OXCARBAZEPINE RIFAMPIN CARBAMAZEPINE (ALSO AUTOINDUCER) ST JOHNS WORT
5
Q
PGP INHIBITORS
A
ANTIINFECTIVES: CLARITHROMYCIN, ITRACONAZOLE
CV DRUGS: AMIODARONE, DILTIAZEM, VERAPAMIL
HIV DRUGS: COBICISTAT, RITONAVIR
HCV DRUGS
OTHERS: CYCLOSPORINE
