Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

NAPLEX 2022 > Infectious Diseases - PART 1 > Flashcards

Infectious Diseases - PART 1 Flashcards

Abx intro, Beta Lactams

1
Q

HYDROPHILLIC ANTIBIOTICS

A

BETA LACTAMS
AMINOGLYCOSIDES
GLYCOPEPTIDES
DAPTOMYCIN
POLYMIXIN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

LIPOPHILIC ANTIBIOTICS

A

QUINOLONES
MACROLIDES
RIFAMPIN
LINEZOLID
TETRACYCLINES

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

HYDROPHILIC ABX CHARACTERISTICS
(V, CL, CONC LEVEL, SEPSIS, F)

A
  • SMALL Vd = POOR TISSUE PENETRATION
  • RENAL EXCRETION - DOSE ADJUST
  • LOW INTRACELL CONC = NOT ACTIVE AGAINST ATYPICAL
  • ↑CL AND DISTRIBUTION = LD + AGGRESSIVE DOSING
  • LOW = NOT USED PO OR IV:PO NOT 1:1
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

LIPOPHILIC ABX CHARACTERISTICS
(V, CL, CONC LEVEL, SEPSIS, F)

A
  • LARGE Vd = GOOD PENETRATION
  • HEPATIC CL = DDI AND TOXICITY
  • HIGH = ACTIVE AGAINST ATYPICAL
  • MINIMAL CHANGE TO CL/D = NO DOSE ADJUSTMENT FOR SEPSIS
  • EXCELLENT = IV:PO = 1:1
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

ABX CONCENTRATION DEPENDENT

A

AMINOGLYCOSIDES
QUINOLONES
DAPTOMYCIN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

EXPOSURE DEPENDENT ABX

A

VANCOMYCIN
MACROLIDES
TETRACYCLINES
POLYMIXINS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

TIME DEPENDENT ABX

A

BETALACTAMS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

NATURAL PENICILLIN COVERAGE

A

GPC (NO STAPH)
GP ANAEROBES (MOUTH FLORA)
NO GN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

ANTISTAPHYLOCOCCAL PENICILLINS COVERAGE

A

GPC (STREP, MSSA, NO ENTEROCOCCI)
NO GN
NO ANAEROBES

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

AMINOPENICILLINS COVERAGE

A

GPC (STREP, ENTEROCOCCI)
GP ANAEROBES (MOUTH FLORA)
GN (HFLU, NEISSERIA, PROTEUS, ECOLI)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

AMINOPENICILLINS + BETALACTAMASE INHIBITORS COVERAGE

A

AMINOPENICILLIN COVERAGE PLUS
MSSA
HNPEK
GN ANAEROBES (BFRAG)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

PIP/TAZO COVERAGE

A

AMINOPENICILLIN/BLI COVERAGE PLUS

INCLUDES MORE GN BACTERIA (CAPES) AND PSEUDOMONAS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

HNPEK

A

HAEMOPHILUS
NEISSERIA
PROTEUS
ECOLI
KLEBSIELLA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

CAPES

A

CITROBACTER
ACTINOBACTER
PROVIDENCIA
ENTEROBACTER
SERRATIA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

PEK

A

GN RODS
PROTEUS
ECOLI
KLEBSIELLA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

1ST GEN CEPHALOSPORINS COVERAGE

A

EXCELLENT GPC (STREP AND MSSA)
SOME GNR (PEK) BUT NOT GREAT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

2ND GEN CEPHALOSPORINS COVERAGE

A

CEFUROXIME
STAPH
STREP PNEUMO
HNPEK

CEFOTETAN - ADDS GN ANAEROBE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

3RD GEN CEPHALOSPORINS COVERAGE: GROUP 1

A

RESISTANT STREPTOCOCCI
MSSA
GP ANAEROBES (MOUTH)
RESISTANT HNPEK

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

3RD GEN CEPHALOSPORINS COVERAGE: GROUP 2

A

NO GPC
PSEUDOMONAS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

4TH GEN CEPHALOSPORINS COVERAGE

A

BROAD GN (HNPEK, CAPES, PSEUDOMONAS)
GPC (RESISTANT STREP, MSSA)
GP ANAEROBES (MOUTH)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

5TH GEN CEPHALOSPORINS COVERAGE

A

BROAD GP
ONLY BETALACTAM TO COVER MRSA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

WHICH BETA LACTAM IS THE ONLY ONE TO COVER MRSA

A

CEFTAROLINE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

ADDING BETALATAMASE INHIBITORS TO CEPHALOSPORINS ADDS WHAT COVERAGE?

A

MDR PSEUDOMONAS
MDR GNR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

1ST GENERATION CEPHALOSPORINS (FORMULATION)

A

CEFAZOLIN (IV/IM)
CEPHALEXIN (PO)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
2ND GENERATION CEPHALOSPORINS (FORMULATION)
CEFUROXIME (PO/IV/IM) CEFOTETAN (IV/IM)
26
3RD GENERATION CEPHALOSPORINS GROUP 1 (FORMULATION)
CEFDINIR (PO) CEFTRIAXONE (IV/IM) CEFOTAXIME (IV/IM) CEFIXIME (PO) CEFPODOXIME (PO)
27
3RD GENERATION CEPHALOSPORINS GROUP 2 (FORMULATION)
CEFTAZIDIME (IV/IM)
28
4TH GENERATION CEPHALOSPORINS (FORMULATION)
CEFEPIME (IV/IM)
29
5TH GENERATION CEPHALOSPORINS (FORMULATION)
CEFTAROLINE
30
CEPHALOSPORIN IV COMPATIBILITY?
CEFTRIAXONE CAN FORM INSOLUBLE PRECIPITATES WITH CA CONTAINING IV FLUIDS
31
WHICH CEPHALOSPORIN DOES NOT NEED RENAL ADJUSTMENT?
CEFTRIAXONE
32
WHICH CEPHALOSPORIN CAN CAUSE A DISULFIRAM-LIKE REACTION?
CEFOTETAN
33
COMMON USE: CEPHALEXIN
SKIN INFECTIONS (MSSA) STREP THROAT
34
COMMON USE: CEFUROXIME
AOM CAP OUTPATIENT SINUS INFECTIONS
35
COMMON USE: CEFDINIR
CAP OUTPATIENT SINUS INFECTIONS
36
COMMON USE: CEFAZOLIN
SURGICAL PROPHYLAXIS
37
COMMON USE: CEFOTETAN AND CEFOXITIN
SURGICAL PROPHYLAXIS
38
COMMON USE: CEFTRIAXONE AND CEFOTAXIME
CAP INPATIENT MENINGITIS SBP PYELONEPHRITIS
39
COMMON USE: CEFTAZIDIME AND CEFEPIME
PSEUDOMONAS
40
COMMON USE: CEFTAROLINE
MRSA CAP INPATIENT SKIN TISSUE INFECTION
41
COMMON USE: PENICILLIN VK
STREP THROAT MILD NONPURULENT SKIN INFECTION
42
COMMON USE: AMOXICILLIN
AOM INFECTIVE ENDOCARDITIS PROPHYLAXIS PRIOR TO DENTAL PROCEDURE
43
AMOXICILLIN PEDIATRIC DOSE
80-90 MG/KG/DAY
44
COMMON USE: PENICILLIN G BENZATHINE
SYPHILIS
45
HOW IS PENICILLIN G BENZATHINE ADMINISTERED
IM ONLY CAN CAUSE DEATH IF IV
46
WHICH PENICILLIN IS ACTIVE AGAINST PSEUDOMONAS
PIPERACILLIN/TAZOBACTAM
47
WHICH SCENARIO WOULD ONE USE PENICILLIN IN PT WITH PENICILLIN ALLERGY?
SYPHILLIS IN PREGNANCY DESENSITIZE AND TREAT
48
PENICILLIN IV COMPATIBILITY?
IV AMPICILLIN MUST BE DILUTED IN NS ONLY
49
CARBAPENEM COVERAGE
MOST GP, GN (INCLUDING ESBL AND PSEUDOMONAS) AND ANAEROBIC NO COVERAGE TO ATYPICAL, MRSA, VRE
50
WHICH CARBAPENEM IS AN EXCEPTION FROM THE OTHERS AND WHY?
ERTAPENEM NO ACTIVITY AGAINST PSEUDOMONAS, ENTEROCOCCUS, ACITENOBACTER EAP - PEA
51
CARBAPENEM IV COMPATIBILITY?
ERTAPENEM IS ONLY STABLE IN NS
52
WHAT DO CARBAPENEMS NOT COVER?
ATYPICALS VRE MRSA C DIFF
53
MONOBACTAM AGENTS
AZTREONAM
54
CAN AZTREONAM BE USED IN PCN ALLERGY?
YES
55
AZTREONAM COVERAGE
GN (INCLUDING PSEUDOMONAS) NO GP OR ANAEROBIC COVERAGE
56
NATURAL PENICILLIN AGENTS
PENICILLIN V POTASSIUM PENICILLIN G BENZATHINE
57
ANTISTAPHYLOCOCCAL PENICILLINS
DICLOXACILLIN NAFCILLIN OXACILLIN
58
AMINOPENICILLIN AGENTS (BETA LACTAMASE INHIBITOR COUNTERPART)
AMOXICILLIN (+CLAVULANATE) AMPICILLIN (+SULBACTAM)
59
EXTENDED SPECTRUM PENICILLIN AGENT
PIPERACILLIN TAZOBACTAM
60
CONTRAINDICATIONS FOR AMOXICILLIN
SEVERE RENAL IMPAIRMENT (CRCL <30) DO NOT USE ER FORMS OR THE 875 MG STRENGTH OF AUGMENTIN
61
BETA LACTAM SIDE EFFECT (SHARED AMONG ALL THE CLASSES)
- SEIZURES (IF NOT DOSE ADJUSTED) - GI UPSET, DIARRHEA - RASH, SJS/TENS, ALLERGIC REACTION - HEMOLYTIC ANEMIA (POSITIVE COOMBS TEST)
62
CAUTION WITH NAFCILLIN
VESSICANT - IF EXTRAVASATION OCCURS, USE COLD PACKS AND HYALURONIDASE
63
WHICH PENICILLIN CLASS DOES NOT NEED TO BE RENAL DOSE ADJUSTED?
ANTISTAPH PENICILLINS (DICLOXACILLIN, NAFCILLIN, OXACILLIN)
64
CEFTRIAXONE CONTRAINDICATION
- HYPERBILIRUBINEMIC NEONATES - CONCURRENT USE WITH CA CONTAINING IV PRODUCTS IN NEONATES
65
CEFOTETAN WARNING
SIDE CHAIN CAN ↑ RISK OF BLEEDING AND CAUSE DISULFIRAM REACTION
66
CEFTAZIDIME/AVIBACTAM COMBO (AVYCAZ) COVERAGE
ALSO HAS ACTIVITY AGAINST CARBAPENEM-RESISTANT ENTEROBACTERIACEAE (CRE)

NAPLEX 2022 (37 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions