HIV - GENERAL INFORMATION Flashcards
WHEN IS AIDS DIAGNOSED
WHEN CD4 COUNT FALLS BELOW 200 CELLS/MM2
SIGNS OF ACUTE HIV INFECTION
FLU LIKE SYMPTOMS
HOW LONG AFTER INFECTION WILL ONE BE ABLE TO DETECT ANTIGENS AND ANTIBODIES?
ANTIGENS ~ 2 WEEKS POST INFECTION
ANTIBODIES ~4-12 WEEKS POST INFECTION
HIV1/HIV2 ANTIGEN/ANTIBODY IMMUNOASSAY
TESTS FOR P24 ANTIGENS AND HIV1/HIV2 ANTIBODIES
USED FOR INITIAL SCREENING
HIV1/HIV2 ANTIBODY DIFFERENTIATION IMMUNOASSAY
CONFIRMATORY TESTING
IF POSITIVE - HIV DIAGNOSIS AND SUBTYPE CONFIRMED
IF NEGATIVE OR INDETERMINATE - ADDITIONAL TEST NEEDED TO QUANTIFY VIRAL LOAD
HIV1 NUCLEIC ACID TEST
QUANTIFIES VIRAL LOAD
OTC HIV TEST
ORAQUICK
DETECTS HIV ANTIBODIES
POSITIVE RESULTS MUST FOLLOW UP WITH CONFIRMATORY LAB TEST
SHOULD BE TAKEN ≥ 3 MONTHS POST EXPOSURE
PREFERRED INITIAL ART REGIMENS IN MOST TREATMENT NAIVE ADULTS
- ONE PILL ONCE DAILY REGIMENS
BIKTARVY
TRIUMEQ
DOVATO
PREFERRED INITIAL ART REGIMENS IN MOST TREATMENT NAIVE ADULTS
- TWO PILLS ONCE DAILY REGIMENS
TIVICAY + TRUVADA
TIVICAY + DESCOVY
ISSENTRESS + TRUVADA
ISSENTRESS + DESCOVY
MOST PREFERRED INITIAL ART REGIMENS IN TREATMENT NAIVE ADULTS CONTAINS WHICH CLASSES?
2 NRTIS AND 1 INSTI
WHICH NRTIS MAKE UP THE BACKBONE OF MOST REGIMENS?
TRUVADA (EMTRICITABINE / TDF)
DESCOVY (EMTRICITABINE / TAF)
WHICH NRTIS COMMONLY USED ARE INTERCHANGEABLE?
LAMIVUDINE AND EMTRICITABINE
TDF OR TAF OR ABACAVIR
WHICH OF THE “ONE PILL, ONCE DAILY” OPTIONS IS DIFFERENT FROM THE OTHERS AND WHY?
DOVATO - ONLY 2 COMPONENTS (1 NRTI + 1 INSTI)
DO NOT USE IN TREATMENT NAIVE PATIENTS IF
- HIV VIRAL LOAD IS HIGH (>500,000)
- HAVE KNOWN HBV OR UNKNWON HBV STATUS, OR
- HIV GENOTYPING TESTING NOT YET AVAILABLE
WHICH OF THE “ONE PILL, ONCE DAILY” OPTIONS REQUIRES EXTRA TESTING?
TRIUMEQ - CONTAINS ABACAVIR
NEED TO TEST FOR HLA-B*5701 ALLELE
WHICH OF THE “ONE PILL, ONCE DAILY” OPTIONS IS MORE FLEXIBLE WITH RENAL DOSING
NONE
HOWEVER, BIKTARVY REGIMEN CAN BE GIVEN IN INDIVIDUAL COMPONENTS FOR MORE DOSE ADJUSTMENTS
