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ASS PHARMA > Synthetic antibacterials and unclassified antibiotics > Flashcards

Synthetic antibacterials and unclassified antibiotics Flashcards

1
Q

Synthetic fluorinated analagos of Nalidixic acid

A

Quinolones

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2
Q

Most potent fluroquinolone

A

Ciprofloxacin

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3
Q

fluroquinolone MOA

A

inhibition of DNA synthesis due to the inhibition of DNA gyrase (TOPOISOMERASE II)
[flower inhibits gay]

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4
Q

fluroquinolone used as urinary antiseptic, used in pregnancy

A

Nitrofurantoin

not used in nursing, enters the breastmilk

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5
Q

fluroquinolone used in the treatment of trypanosoma cruzi infection( chaga’s disease)

A

Nifurtimox

[cruzi- timos timos]

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6
Q

DOC for G. Lamblia, E. histolytica, T. vaginalis

assoc. with metalic taste, disulfiram effect iff taken with alcohol

A

Metronidazole

[doc for G E T, Metal: Metro ]

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7
Q

Structural analog for PABA, compete with this stubstrate for the enzyme dihydropteroate synthetase, prevent synthesis of bacterial folic acid

A

Sulfonamide

[sulfolic acid]

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8
Q

adverse effects of Sulfonamide

A

Steven johnson’s syndrome

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9
Q

Sulfonamide indicated for UTI

A

Cotrimoxazole

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10
Q

Sulfonamide indicated for burn therapy

A

silver sulfadiazine

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11
Q

Sulfonamide indicated for chlorquine resistant malaria

A

FANSIDAR (quinine, pyrimethamine, sulfadoxime)

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12
Q

Sulfonamide indicated for Pneumocystis carinii

A

Cotrimoxazole

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13
Q

MCC of SJS (3)

A

Sulfonamides, aromatic Anticonvulsants, Allopurinol

[SAllo Steven Anti]

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14
Q

Sulfones used to tread leprosy

A

Dapsone

[dats one cellphone: give to leprosy pt]

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15
Q

Sulfones associated with methemoglobinemia and Hemolyitc anemia in G6PD

A

Dapsone

[dats one cellphone]

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16
Q

drug derived form streptomyces venezuelae
Inhibits protein synthesis at 50s ribosomal subunit
DOC of typhoid fever

A

Chloramphenicol

[(chlor) color sa imong tae?(typhoid)]

17
Q

Chloramphenicol adverse reaction

A

gray baby syndrome (chlorampheni cool: gray)

aplastic anemia

18
Q

topical antibiotic from pseudomonas fluorescens,

impetigo, eczema, inhibits RNA and DNA synthesis

A

Mupirocin

ASS PHARMA (16 decks)

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