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ASS PHARMA > Autacoids, anti inflammatory, analgesics > Flashcards

Autacoids, anti inflammatory, analgesics Flashcards

1
Q

Autoacoid chemical classification

A 
amines: histamines, 5 HT
small peptides: kinins
large peptides: interleukins
lipids: eicosanoids
angiotensin
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2
Q

Vasoconstrictor, derived from angiotensinogen, important in RAAS

A

Angiotensin

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3
Q

Physiologic antihistamine

A

epinephrine

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4
Q

Classic antihistamines (h1)

A

Piperazines Ethanolamines Phentolazines alkylazines

[PEPA ka kung di ka muburot] mines+ zines

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5
Q

DOC for motionsickness

A

diphenhydramine

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6
Q

DOC for antiemesis

A

promethazine

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7
Q

DOC for mild anxiety

A

Hydoxyzine pamoate

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8
Q

DI: antihistamine+ alcohol

A

addition of CNS depression

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9
Q

DI: antihistamine+ MAOI

A

anticholinergic effects (BOV, drymouth, dysuria, constipation)

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10
Q

DI: antihistamine+ clarithromycin/erythromycin

A

arrhytmias

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11
Q

DOC for duodenal ulcers, zollinger ellision, GER

A

Cimetidine, ranitidine, famotidine, nizatidine

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12
Q

cells that produce histamine (4)

A

mast cells, basophils, eosinophils, enterochromaffin cells

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13
Q

receptors in the stomach regulating acidity

A

acetylcholine
gastrin -produced by g cells
h2- activated by enterochromaffin cells

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14
Q

SE of cimetidine

A

gynecomastia

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15
Q

aka 5-HT

A

serotonin

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16
Q

precursor of serotonin

A

tryptophan

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17
Q

location of serotonin

A

Enterochromaffin cells, brain, platelets

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18
Q

serotonin affects:

A

Body temp, Emotion, Appetite, mood, sleep

[BEAMS]

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19
Q

Monoamines (3)

A

serotonin, norepinephrine, epinephrine

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20
Q

food that have been aged or fermented are rich in?

A

tyramine

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21
Q

MAOI with anti parkinson effect

A

Selegeline

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22
Q

MAO+ Tyramin rich food causes this condition

A

hypertensive crisis

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23
Q

Atypical antidepressant with anti dopaminergic, anti noradrenergic effect, used in smoking cessation

A

bupropion

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24
Q

Atypical antidepressant with anti alpha 2 (presynaptic) effect, post synaptic serotonin and antihistamine activity

A

mirtazapine

25
Q

Atypical antidepressant with anti serotonergic reupatake, ht2, histamine, alpha 1 effect

A

trazodone

nefazodone

26
Q

partial serotonin receptor agonist and reuptake antagonist

A

vilazodone

27
Q

partial serotonin receptor agonist, antagonist and reuptake antagonist

A

vortioxetine

28
Q

Prostaglandin DOC of erectile dysfunction

A

alprostadil(PGE1)

29
Q

Prostaglandin used to decrease acid secretion, induce uterine contraction

A

misoprostol(PGE1)

30
Q

Prostaglandin DOC for glaucoma

A

Latanoprost (PGF2a)

31
Q

Prostaglandin DOC for Pulmonary hypertension

A

Iloprost(PGI2) aka prostacyclin

32
Q

responsible for vasconstriction

A

TXA2 (thromboxane)
PGF2A (dinoprost)
[Tax and pf]

33
Q

responsible for vasodilatation

A

PGI2 (Prostacycline)
PGE2 (dinoprostone)
[pig and peg is dilated]

34
Q

responsible for bronchoconstriction

A

TXA2
LTD4 (leukotrienes)
LTC4 (leukotrienes)

35
Q

responsible for bronchodilation

A

PGI2, PGF2A

36
Q

responsible for platelet aggregation

37
Q

responsible for inhibition of platelet aggregation

A

PGE1 (alprostadil)

PGI2

38
Q

eosinophilic granulomatosis with polyangiitis

A

Churg-strauss syndromw

condition that causes inflammation of small and medium-sized blood vessels

39
Q

drugs used for rheumatologic disorders

A

NSAIDS, DMARDS, SAARDS

40
Q

drugs used for gout

A

Colchicine, Allopurinol, Uricosuric agents, NSAIDS

[CAUN]

41
Q

Diagnostic Criteria for RA

A 
Morning stiffness >30mins
Swelling of atleast 3 joint areas
arthritis of the hand joints
symmetrical
RA nodules
increased RF, IgM, IgE, ESR
bone erosion, and cartilage loss
42
Q

Hallmark of RA

A

Inflamed synovium

43
Q

NSAID prototype drug

44
Q

DOC for IBD or Chron’s disease

A

Sulfasalazine

45
Q

Clinical uses of Aspirin (4)

A
  1. anti-inflammatory 3.2-4g/day
  2. analgesic < .6g/day
  3. antipyretic .3-.2.4 .
  4. anti-platelet less than or equal to 325mg/day
46
Q

NSAID causing infertility

A

Sulfasalazine

47
Q

NSAiD causing fatal fulminating hepatitis with cerebral edema

A

Reye’s Syndrome

48
Q

NSAID used in closure of PDA

A

Indomethacin

49
Q

drugs used for rheumatic disorders that does not respond to NSAIDS

A

DMARDS/SAARDS

50
Q

1st line DMARDS, immunosuppressants

A

Methotrexate

(others: azathioprine, cyclophosphamide, chlorambucil),

51
Q

Antimalarials (2)

A

Chloroquine, Hydroxychloroquine

52
Q

antidote of heavy metal poisoning

A

Penicillamine

[penis is for heavy metal]

53
Q

hyperurecemia is acondition characterized by increased uric acid level of by how much

A

uric acid >7mg/dL

54
Q

a disease characterized by sudden attacks of urate-crystal induced arthritis

A

gout/ gouty arthritis

55
Q

gout/ gouty arthritis commonly affects this are

A

big toe “tophi”

56
Q

gouty arthritis diagnostic criteria (3)

A
  1. monosodium urate crystals in the synovial fluid
  2. serum uric acid elevation, and leukocytosis
  3. respond to colchicine
57
Q

DOC for an acute gout attack

MOA: Impairs leukocyte migration to inflamed areas and disrupts urate deposition

A

Colchicine

58
Q

DOC for an acute gout attack

MOA: Inhibit xanthine oxidase

A

Allopurinol

59
Q

DOC for an acute gout attack

MOA: increase uric acid secretion in the proximal tubules

A

Probenecid and Sulfinpyrzone

ASS PHARMA (16 decks)

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