Antimalarials Flashcards
strutural feature of all antimalarials
Quinoline ring
reserved for malarial strains resistant to other agents
Quinine
major adverse effect of quinine
cinchonism (nausea, vomiting, tinnitus, vertigo)
DOC for Falcifarum malaria, extraintestinal amoebias
Chloroquine
[chloro:falci, klaro:false]
antimalarial with anti inflammatory action, used in RA, lupus
Hydroxychloroquine
[hydro: rehydrate pts with RA, Lupus]
Highly suppressive in Plasmodium vivax and P. falciparum
Amodiaquine
[suppressive ang amo]
Effective only against the exoerythrocytic stages of malaria, gametocidal in all 4 plasmodia species
Primaquine
[Prime exo]
antimalarial primarily used in the treatment of Giardiasis, also effective against tapeworm and malaria, topically against leishmaniasis
Quinacrine
[Queen’s guard]
Effective as single agent for suppressing and curing multidrug resistant form of plasmodium falciparum
Mefloquine
[single:me, false]