Anti tubercular agents

Question 1

Facultative intracellular organism, obligate aerobe

Answer 1

Mycobacterium tuberculosis

Question 2

MTB culture medium

Answer 2

Lowenstein Jensen Medium

Question 3

characteristic growth pattern of MTB on culture medium

Answer 3

serpentine growth

Question 4

anti TB drug that inhibits the synthesis of mycolic, adverse effect: peripheral neuritis

Answer 4

Isoniazid

Question 5

prevention of peripheral neuritis on INH

Answer 5

Pyridoxine (vit b 6)

Question 6

antidote of INH toxicity

Answer 6

Pyridoxine (vit b 6)

Question 7

first line of drug for short term treatment of MTB,

adverse effect: hepatotoxicity

Answer 7

Pyrazinamide

Question 8

adverse effect: loss of ability to discriminate red and green. adverse effect: optic neuritis

Answer 8

ethambutol

Question 9

structural analogue of isoniazid, used in the treatment of isoniazid resistant tuberculosis

Answer 9

Ethionamid

Question 10

Basic red dye used in the treatment of leprosy, inculding dapsone resistant form

Answer 10

clofazimine

[lofa: fola: Pula for red dye]

Question 11

Most active agent for MTB treatment

adverse effect: reddish color of body secretions

Answer 11

rifampicin

[R red}

Question 12

TB med used as prophylaxis of meningococcemia

Answer 12

rifampicin

Question 13

only aminoglycoside used for TB

Answer 13

streptomycin

Question 14

first antibiotic effective in the treatment of tuberculosis

Answer 14

streptomycin